0001213900-24-021982 | 10-K | XBRL Viewer

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Summary of Significant Accounting Policies (Details) - Schedule of Cash, Cash Equivalents and Restricted Cash - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Cash and Cash Equivalents, at Carrying Value [Abstract]
Cash and cash equivalents	$ 39,586	$ 24,127
Restricted cash, non-current	745	745
Total cash, cash equivalents and restricted cash shown in the consolidated statements of cash flows	$ 40,331	$ 24,872	$ 36,469

Net Loss Per Common Share (Details) - Schedule of Net Loss Per Share Attributable to Common Stockholders, Basic and Diluted (Parentheticals) - $ / shares	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Schedule of Net Loss Per Share Attributable to Common Stockholders Basic and Diluted [Abstract]
Weighted-average common shares outstanding – diluted	11,331,338	11,259,615
Net loss per share attributable to common stockholders, diluted	$ (3.57)	$ (5.86)

- Definition

The amount of net income (loss) for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period.

+ References

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+ Details

Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Operating expenses:
Research and development	$ 24,989	$ 16,808
General and administrative	18,624	20,737
Loss on impairment of goodwill		29,517
Total operating expenses	43,613	67,062
Loss from operations	(43,613)	(67,062)
Other income (expense), net:
Interest and investment income	3,193	1,110
Other income (expense), net	3,193	1,110
Net loss	$ (40,420)	$ (65,952)
Net loss per share attributable to common stockholders, basic (in Dollars per share)	$ (3.57)	$ (5.86)
Weighted average shares outstanding, basic (in Shares)	11,331,338	11,259,615
Other comprehensive income (loss):
Net unrealized gain (loss) on marketable debt securities	$ 657	$ (477)
Other comprehensive income (loss)	657	(477)
Comprehensive loss	$ (39,763)	$ (66,429)

Property and Equipment, Net

12 Months Ended

Dec. 31, 2023

Property and Equipment, Net [Abstract]

Property and Equipment, net

6. Property and Equipment, net

Property and equipment, net consists of the following as of:

	December 31,
	2023			2022
Computer equipment	$	247		$	205
Furniture, fixtures and other		352			352
Laboratory equipment		913			866
Leasehold improvements		553			553
Property and equipment not yet placed into service		55			99
Total property and equipment		2,120			2,075
Less: Accumulated depreciation		(824	)		(483	)
Total property and equipment, net	$	1,296		$	1,592

Depreciation expense was $341 and $247 for the years ended December 31, 2023 and 2022, respectively. During the year ended December 31, 2023, $204 and $137 was included in research and development expense and general and administrative expense, respectively, within the consolidated statements of operations and comprehensive loss. During the year ended December 31, 2022, $137 and $110 was included in research and development expense and general and administrative expense, respectively, within the consolidated statements of operations and comprehensive loss. As of December 31, 2023 and 2022, 100% of the Company’s total property and equipment, net was attributable to the United States.

Other Assets (Tables)

12 Months Ended

Dec. 31, 2023

Other Assets [Abstract]

Schedule of Other Assets

Other assets consists of the following as of:

	December 31,
	2023		2022
Prepaid research and development, non-current	$	2,661	$	84
Prepaid insurance, non-current		272		544
Other non-current assets		11		16
Total	$	2,944	$	644

Stock-Based Compensation (Details) - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Jan. 01, 2024	Jan. 01, 2023	Jan. 01, 2020	Oct. 03, 2014
Stock-Based Compensation [Line Items]
Common stock subject to outstanding awards	11,364,903	11,267,389
Common stock shares	39,087
Common Stock, Shares, Issued	11,364,903	11,267,389
Weighted average grant fair value per share (in Dollars per share)	$ 2.99
2020 Inducement Plan [Member]
Stock-Based Compensation [Line Items]
Common stock shares	600,000
Common stock subject to outstanding awards	409,000
Common stock shares	191,000
2017 Equity Incentive Plan [Member]
Stock-Based Compensation [Line Items]
Common stock shares	2,000,000
2014 Equity Incentive Plan [Member]
Stock-Based Compensation [Line Items]
Common stock shares					1,048,300
Amended and Restated 2014 Plan [Member]
Stock-Based Compensation [Line Items]
Common stock subject to outstanding awards	2,883,056
Common stock shares	547,382
2014 Employee Stock Purchase Plan [Member]
Stock-Based Compensation [Line Items]
Common stock shares	39,087					3,513
Employee stock purchase plan increase, description	The number of shares increases each January 1, commencing on January 1, 2015 and ending on (and including) January 1, 2024, by an amount equal to the lesser of one percent of the outstanding shares as of the end of the immediately preceding fiscal year, 7,025 shares or any lower amount determined by the Company’s Board of Directors prior to each such January 1st.
Minimum [Member] \| Amended and Restated 2014 Plan [Member]
Stock-Based Compensation [Line Items]
Number of shares authorized and increased				861,933
Minimum [Member] \| 2014 Employee Stock Purchase Plan [Member]
Stock-Based Compensation [Line Items]
Number of shares authorized and increased				7,025
Maximum [Member] \| Amended and Restated 2014 Plan [Member]
Stock-Based Compensation [Line Items]
Common stock shares				3,563,303
Maximum [Member] \| 2014 Employee Stock Purchase Plan [Member]
Stock-Based Compensation [Line Items]
Common stock shares				39,087
Subsequent Event [Member] \| Minimum [Member] \| Amended and Restated 2014 Plan [Member]
Stock-Based Compensation [Line Items]
Number of shares authorized and increased			911,380
Subsequent Event [Member] \| Minimum [Member] \| 2014 Employee Stock Purchase Plan [Member]
Stock-Based Compensation [Line Items]
Number of shares authorized and increased			7,025
Subsequent Event [Member] \| Maximum [Member] \| Amended and Restated 2014 Plan [Member]
Stock-Based Compensation [Line Items]
Common stock shares			4,474,683
Subsequent Event [Member] \| Maximum [Member] \| 2014 Employee Stock Purchase Plan [Member]
Stock-Based Compensation [Line Items]
Common stock shares			46,112
Restricted Stock Units (RSUs) [Member]
Stock-Based Compensation [Line Items]
Unrecognized share based compensation (in Dollars)	$ 569
Recognized over a weighted average period	1 year 6 months 18 days
Number of RSUs	289,500	289,500
Common Stock, Shares, Issued	61,691
Number of RSUs Settled	94,528
Net share settlement (in Dollars)	$ 91
Stock Options [Member]
Stock-Based Compensation [Line Items]
Unrecognized share based compensation (in Dollars)	5,699
Recognized over a weighted average period		2 years 7 months 2 days
Intrinsic value of options exercised (in Dollars)	$ 0	$ 0
Weighted average grant fair value per share (in Dollars per share)	$ 2.36	$ 4.8

Marketable Debt Securities (Details) - Schedule of Marketable Debt Securities - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Marketable Securities [Line Items]
Amortized Cost	$ 26,025	$ 78,817
Unrealized Gains
Unrealized Losses	(31)	(688)
Estimated Fair Value	25,994	78,129
Corporate bonds - presented in marketable debt securities [Member]
Marketable Securities [Line Items]
Amortized Cost	23,525	60,790
Unrealized Gains
Unrealized Losses	(30)	(547)
Estimated Fair Value	23,495	60,243
Agency bonds – presented in marketable debt securities [Member]
Marketable Securities [Line Items]
Amortized Cost	2,500
Unrealized Gains
Unrealized Losses	(1)
Estimated Fair Value	$ 2,499
Corporate bonds - presented in marketable debt securities, non-current [Member]
Marketable Securities [Line Items]
Amortized Cost		18,027
Unrealized Gains
Unrealized Losses		(141)
Estimated Fair Value		$ 17,886

Other Assets (Details) - Schedule of Other Assets - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Other Assets [Abstract]
Prepaid research and development, non-current	$ 2,661	$ 84
Prepaid insurance, non-current	272	544
Other non-current assets	11	16
Total	$ 2,944	$ 644

Leases (Details) - Schedule of Operating Lease Payments Included in the Measurement of Lease Liabilities $ in Thousands	Dec. 31, 2023 USD ($)
Lessee, Operating Lease, Liability, to be Paid, Fiscal Year Maturity [Abstract]
2024	$ 1,327
2025	1,395
2026	1,429
2027	1,429
2028	718
Thereafter	87
Total future operating lease payments	6,385
Less: imputed interest	(918)
Present value of future minimum lease payments	$ 5,467

Net Loss Per Common Share (Details) - Schedule of Weighted Average Dilutive Common Shares - shares	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total potentially dilutive shares	11,419,601	10,343,706
Stock options issued and outstanding [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total potentially dilutive shares	2,900,205	1,828,329
Restricted stock units issued and outstanding [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total potentially dilutive shares	526,179	486,338
Conversion of Series 1 Convertible Preferred Stock [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total potentially dilutive shares	7,993,217	8,029,039

Net Loss Per Common Share (Tables)

12 Months Ended

Dec. 31, 2023

Net Loss Per Common Share [Abstract]

Schedule of Net Loss Per Share Attributable to Common Stockholders, Basic and Diluted

The following table sets forth the computation of the net loss per share attributable to common stockholders, basic and diluted:

	December 31,
	2023			2022
Numerator:
Net loss attributable to common stockholders	$	(40,420	)	$	(65,952	)
Denominator:
Weighted-average common shares outstanding – basic and diluted		11,331,338			11,259,615
Net loss per share attributable to common stockholders, basic and diluted	$	(3.57	)	$	(5.86	)

Schedule of Weighted Average Dilutive Common Shares

The Company excluded the following potential common shares, presented based on amounts outstanding at each period end, from the computation of diluted net loss per share attributable to common stockholders for the periods indicated because including them would have had an anti-dilutive effect:

	December 31,
	2023		2022
Stock options issued and outstanding		2,900,205		1,828,329
Restricted stock units issued and outstanding		526,179		486,338
Conversion of Series 1 Convertible Preferred Stock		7,993,217		8,029,039
Total potentially dilutive shares		11,419,601		10,343,706

Stock-Based Compensation (Details) - Schedule of the Fair Value of Stock Options Granted - $ / shares	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Stock-Based Compensation [Line Items]
Dividend yield	0.00%	0.00%
Minimum [Member]
Stock-Based Compensation [Line Items]
Exercise price (in Dollars per share)	$ 1.2	$ 2.77
Expected volatility	90.00%	92.00%
Risk-free interest rate	3.46%	1.46%
Expected life (in years)	5 years 3 months 7 days	5 years 3 months 7 days
Maximum [Member]
Stock-Based Compensation [Line Items]
Exercise price (in Dollars per share)	$ 3.91	$ 6.9
Expected volatility	98.00%	99.00%
Risk-free interest rate	4.73%	4.23%
Expected life (in years)	6 years 29 days	6 years 29 days

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

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+ Details

Stockholders’ Equity (Details)	12 Months Ended
Stockholders’ Equity (Details)	Dec. 31, 2023 $ / shares shares	Dec. 31, 2022 $ / shares shares
Stockholders’ Equity [Line Items]
Common stock authorized	100,000,000	100,000,000
Common shares of par value (in Dollars per share) \| $ / shares	$ 0.001	$ 0.001
Common stock shares issued	11,364,903	11,267,389
Common stock, shares outstanding	11,364,903	11,267,389
Preferred stock, shares authorized	10,000,000	10,000,000
Preferred stock, par value (in Dollars per share) \| $ / shares	$ 0.001	$ 0.001
Conversion price per share (in Dollars per share) \| $ / shares	$ 7.01
Common Stock [Member]
Stockholders’ Equity [Line Items]
Number of vote per share	one
Series 1 Convertible Preferred Stock [Member]
Stockholders’ Equity [Line Items]
Preferred stock, shares authorized	8,028	8,028
Preferred stock, shares issued	7,991	8,027
Preferred stock, shares outstanding	7,991	8,027
Preferred stock convertible conversion ratio	1,000
Preferred stock conversion limit	9.99%
Convertible preferred stock, percentage	19.99%
Preferred stock, liquidation preference per share (in Dollars per share) \| $ / shares	$ 10
Converted share of common stock	35,823
Series 1 Convertible Preferred Stock [Member] \| Common Stock [Member]
Stockholders’ Equity [Line Items]
Preferred shares redeemed during conversion	36

Leases (Details) - Schedule of Lease Expense - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Schedule of Lease Expense [Abstract]
Operating lease expense	$ 1,423	$ 1,366
Short-term lease expense		3
Total	$ 1,423	$ 1,369

Other Assets

12 Months Ended

Dec. 31, 2023

Other Assets [Abstract]

Other Assets

7. Other Assets

Other assets consists of the following as of:

	December 31,
	2023		2022
Prepaid research and development, non-current	$	2,661	$	84
Prepaid insurance, non-current		272		544
Other non-current assets		11		16
Total	$	2,944	$	644

Marketable Debt Securities (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Marketable Debt Securities [Abstract]
Realized gains and losses	$ 0	$ 17
Unrealized loss is related to expected credit losses

Employee Benefit Plan

12 Months Ended

Dec. 31, 2023

Employee Benefit Plan [Abstract]

Employee Benefit Plan

14. Employee Benefit Plan

The Company maintains a defined contribution benefit plan under section 401(k) of the Internal Revenue Code covering substantially all qualified employees of the Company, or the 401(k) Plan. Under the 401(k) Plan, the Company matches 100% of employee contributions up to 4% of employee compensation. For the years ended December 31, 2023 and 2022, the Company recorded expense of $237 and $223, respectively, representing employer contributions under the 401(k) Plan.

Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Cash flows from operating activities:
Net loss	$ (40,420)	$ (65,952)
Adjustments to reconcile net loss to net cash used in operating activities:
Loss on impairment of goodwill		29,517
Stock based compensation	6,092	6,688
Operating lease right-of-use asset	1,013	1,366
Depreciation	341	248
Amortization of premium (Accretion of discount) on marketable debt securities	(444)	1,137
Changes in operating assets and liabilities:
Prepaid expenses and other current assets	(1,265)	265
Other assets	(2,300)	222
Accounts payable	848	631
Accrued expenses	(505)	748
Operating lease liabilities	(917)	(1,327)
Net cash provided by (used in) operating activities	(37,557)	(26,457)
Cash flows from investing activities:
Purchase of marketable debt securities	(12,186)	(43,550)
Proceeds from maturity and redemption of marketable debt securities	65,338	58,620
Purchase of property and equipment	(45)	(120)
Net cash provided by (used in) investing activities	53,107	14,950
Cash flows from financing activities:
Repurchase of shares in connection with settlement of RSUs	(91)	(90)
Net cash provided by (used in) financing activities	(91)	(90)
Net increase (decrease) in cash and cash equivalents and restricted cash	15,459	(11,597)
Cash and cash equivalents and restricted cash - beginning of year	24,872	36,469
Cash and cash equivalents and restricted cash - end of year	40,331	24,872
Cash paid for:
Interest
Income taxes

Accrued Expenses (Details) - Schedule of Accrued Expenses - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Schedule of Accrued Expenses [Abstract]
Employee costs	$ 2,112	$ 2,543
Research and development	440	512
Other expenses	180	182
Total	$ 2,732	$ 3,237

Leases (Tables)

12 Months Ended

Dec. 31, 2023

Leases [Abstract]

Schedule of Lease Expense

The components of lease expense were as follows:

	For the year ended December 31,
Lease expense	2023		2022
Operating lease expense	$	1,423	$	1,366
Short-term lease expense		-		3
Total	$	1,423	$	1,369

Schedule of Weighted Average Remaining Lease Term and the Weighted Average Discount Rate for Operating Leases

The weighted average remaining lease term and the weighted average discount rate for operating leases were:

	For the year ended December 31,
	2023			2022

Weighted-average discount rate		7.0	%		7.0	%
Weighted-average remaining lease term – operating lease (in months)		55			67

Schedule of Operating Lease Payments Included in the Measurement of Lease Liabilities

The total remaining operating lease payments included in the measurement of lease liabilities on the Company’s consolidated balance sheet as of December 31, 2023, was as follows:

For the year ending December 31:	Operating Lease Payments
2024	$	1,327
2025		1,395
2026		1,429
2027		1,429
2028		718
Thereafter		87
Total future operating lease payments		6,385
Less: imputed interest		(918	)
Present value of future minimum lease payments	$	5,467

Organization and Nature of the Business

12 Months Ended

Dec. 31, 2023

Organization and Nature of the Business [Abstract]

Organization and Nature of the Business

1. Organization and Nature of the Business

Overview

Protara Therapeutics, Inc., and its consolidated subsidiaries (“Protara” or the “Company”), is a clinical-stage biopharmaceutical company committed to advancing transformative therapies for the treatment of cancer and rare diseases. Protara’s portfolio includes two development programs utilizing TARA-002, an investigational cell therapy in development for the treatment of non-muscle invasive bladder cancer, or NMIBC, and lymphatic malformations, or LMs. The third program in the portfolio is Intravenous, or IV, Choline Chloride, an investigational phospholipid substrate replacement therapy in development for patients receiving parenteral nutrition, or PN.

Liquidity and Capital Resources

The Company is in the business of developing biopharmaceuticals and has no current or near-term revenues. The Company has incurred substantial clinical and other costs in its drug development efforts. The Company will need to raise additional capital in order to fully realize management’s plans.

The Company believes that its current financial resources are sufficient to satisfy the Company’s estimated liquidity needs for at least 12 months from the date of issuance of these consolidated financial statements.

Fair Value of Financial Instruments

12 Months Ended

Dec. 31, 2023

Fair Value of Financial Instruments [Abstract]

Fair Value of Financial Instruments

3. Fair Value of Financial Instruments

The tables below present information about the Company’s financial instruments that are measured at fair value on a recurring basis as of December 31, 2023 and 2022 and indicates the fair value hierarchy of the valuation techniques the Company utilized to determine such fair value, as described under Note 2, Summary of Significant Accounting Policies.

The following tables present the Company’s financial assets and liabilities that are measured and carried at fair value and indicate the level within the fair value hierarchy of the valuation techniques it utilizes to determine such fair value:

	December 31, 2023
	Level 1		Level 2		Level 3		Total
Cash equivalents:
Money market funds^(a)	$	39,031	$	-	$	-	$	39,031
Restricted cash, non-current:
Money market funds^(b)		745		-		-		745
Marketable debt securities:
Corporate bonds^(c)		-		23,495		-		23,495
Agency bonds^(c)		-		2,499		-		2,499
Total	$	39,776	$	25,994	$	-	$	65,770

	December 31, 2022
	Level 1		Level 2		Level 3		Total
Cash equivalents:
Money market funds^(a)	$	13,284	$	-	$	-	$	13,284
Corporate bonds^(a)		-		2,523		-		2,523
Restricted cash, non-current:
Money market funds^(b)		745		-		-		745
Marketable debt securities:
Corporate bonds^(c)		-		78,129		-		78,129
Total	$	14,029	$	80,652	$	-	$	94,681

(a)	Money market funds and bonds with original maturities of 90 days or less are included within Cash and cash equivalents in the consolidated balance sheets.

(b)	Restricted Money market funds are included within Restricted Cash, non-current in the consolidated balance sheets.

(c)	Bonds with original maturities greater than 90 days are included within Marketable debt securities in the consolidated balance sheets and classified as current or noncurrent based upon whether the maturity of the financial asset is less than or greater than 12 months.

Money market funds are classified as Level 1 within the fair value hierarchy, because they are valued using quoted prices in active markets. Corporate and agency bonds classified as Level 2 within the fair value hierarchy are valued on the basis of prices from an orderly transaction between market participants provided by reputable dealers or pricing services. Prices of these securities are obtained through independent, third-party pricing services and include market quotations that may include both observable and unobservable inputs. In determining the value of a particular investment, pricing services may use certain information with respect to transactions in such investments, quotations from dealers, pricing matrices and market transactions in comparable investments and various relationships between investments. There were no transfers of financial instruments among Level 1, Level 2, and Level 3 during the period presented.

Non-Recurring Fair Value Measurements

During 2022, the Company recorded a goodwill impairment loss of $29.5 million, refer to Note 2 for additional details on the impairment of goodwill. In 2022, the fair value of the Company’s reporting unit was determined using an income approach based on discounted cash flows, or DCF. Determining fair value using a DCF analysis requires the exercise of significant judgment with respect to several assumptions and estimates, including the amount and timing of expected future cash flows and appropriate discount rate to be applied. The expected cash flows used in the DCF analysis were based on the Company’s most recent internal long-range forecast and budget and, for years beyond the budget, the Company’s estimates, which were based, in part, on industry benchmarks and forecasted growth rates. The discount rate used in the DCF analysis was intended to reflect the risks inherent in the expected future cash flows of the respective programs within the Company’s portfolio. The inputs to the DCF model were Level 3 valuation inputs.

- Definition

The entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information.

+ References + Details

Accounting Policies, by Policy (Policies)

12 Months Ended

Dec. 31, 2023

Summary of Significant Accounting Policies [Abstract]

Basis of Presentation

Basis of Presentation

The accompanying consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“U.S. GAAP” or “GAAP”).

Principles of Consolidation

Principles of Consolidation

The consolidated financial statements include the accounts of the Company and its wholly owned subsidiaries. All intercompany balances and transactions have been eliminated in the accompanying consolidated financial statements.

Use of Estimates

Use of Estimates

The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities, revenues, expenses, and related disclosure of contingent assets and liabilities at the date of the consolidated financial statements. Significant items subject to such estimates include but are not limited to research and development accruals as well as contingencies.

On an ongoing basis, the Company’s management evaluates its estimates based on historical and anticipated results, trends, and various other assumptions believed to be reasonable. Actual results could differ from those estimates. The results of any changes in accounting estimates are reflected in the financial statements of the period in which the change becomes evident.

Cash, Cash Equivalents and Restricted Cash

Cash, Cash Equivalents and Restricted Cash

The Company considers all highly liquid instruments with an original maturity of three months or less when acquired to be cash equivalents. Cash and cash equivalents are held in depository and money market accounts and are reported at fair value. The Company’s restricted cash balances consist of cash deposits to collateralize letter of credit obligations.

The following table provides a reconciliation of cash, cash equivalents, and restricted cash in the consolidated balance sheets to the total amount shown in the consolidated statements of cash flows:

	December 31,
	2023		2022
Cash and cash equivalents	$	39,586	$	24,127
Restricted cash, non-current		745		745
Total cash, cash equivalents and restricted cash shown in the consolidated statements of cash flows	$	40,331	$	24,872

Fair Value Measurements

Fair Value Measurements

Accounting Standards Codification, or ASC, Topic 820 “Fair Value Measurements” provides the framework for measuring fair value and establishes a fair value hierarchy that prioritizes the inputs used in pricing the asset or liability. The hierarchy gives the highest priority to unadjusted quoted prices in active markets for identical assets or liabilities (level 1 measurements) and the lowest priority to unobservable inputs (level 3 measurements).

Fair value is defined as the exchange price, or an exit price, representing the amount that would be received upon the sale of an asset or payment to transfer a liability in an orderly transaction between market participants. As a basis for considering market participant assumptions in fair value measurements, the three-tier fair value hierarchy is used to prioritize the inputs in measuring fair value as follows:

●

Level 1 Quoted prices in active markets for identical assets or liabilities.

●

Level 2 Quoted prices for similar assets or liabilities in active markets, quoted prices for identical or similar assets or liabilities in markets that are not active, or other inputs that are observable, either directly or indirectly.

●

Level 3 Significant unobservable inputs that cannot be corroborated by market data.

The carrying amounts of cash and cash equivalents, prepaid expenses and accounts payable approximate their fair values due to the short-term nature of these instruments.

Marketable Debt Securities

Marketable Debt Securities

The Company classifies investments in marketable debt securities with remaining maturities when purchased of greater than three months as available-for-sale. Investments with a remaining maturity date greater than one year are classified as non-current. The cost of securities sold is based on the specific identification method. Interest earned on securities that are classified as available-for-sale are included in interest and investment income.

The Company records investments at fair value with unrealized gains and losses recorded as a component of other comprehensive income (loss) in the consolidated statements of operations and comprehensive loss until realized. Realized gains and losses are reflected in interest and investment income in the consolidated statements of operations and comprehensive loss and are determined using the specific identification method with transactions recorded on a settlement date basis. Fair value is determined based on quoted market rates when observable or utilizing data points that are observable, such as quoted prices, interest rates and yield curves. To determine whether an other-than-temporary impairment exists, the Company considers whether it has the ability and intent to hold the investment until a market price recovery, and whether evidence indicating the recoverability of the cost of the investment outweighs evidence to the contrary. The Company has the ability to hold such securities with an unrealized loss until its forecasted recovery. The Company determined that there was no material change in the credit risk of these investments.

The Company periodically evaluates the need for an allowance for credit losses. This evaluation includes consideration of several qualitative and quantitative factors, including whether it plans to sell the security, whether it is more likely than not it will be required to sell any marketable debt securities before recovery of its amortized cost basis, and if the entity has the ability and intent to hold the security to maturity, and the portion of any unrealized loss that is the result of a credit loss. Factors considered in making these evaluations include quoted market prices, recent financial results, operating trends, and implied values from any recent transactions or offers of investee securities, credit quality of debt instrument issuers, expected cash flows from securities, other publicly available information that may affect the value of the marketable debt security, duration and severity of decline in value and the Company’s strategy and intentions for holding the marketable debt security.

Concentrations of Credit Risk

Concentrations of Credit Risk

Financial instruments, which potentially subject the Company to concentrations of credit risk, consists principally of cash, cash equivalents, restricted cash, and marketable debt securities.

The Company currently invests its excess cash primarily in money market funds and high quality, investment grade marketable debt securities of corporations. The Company has adopted an investment policy that includes guidelines relative to credit quality, diversification and maturities to preserve principal and liquidity.

Property and Equipment, net

Property and Equipment, net

Property and equipment, including leasehold improvements, are recorded at cost less accumulated depreciation and amortization. Depreciation is computed using the straight-line method over the estimated useful life of the asset. Depreciation begins at the time the asset is placed in service. Leasehold improvements are amortized using the straight-line method over the shorter of the lease term or estimated useful life of the asset. Repairs and maintenance costs are expensed as incurred, whereas major improvements are capitalized as additions to property and equipment.

The estimated useful lives for significant property and equipment categories are as follows:

Asset Classification		Estimated Useful Life
Computer equipment		3-5 years
Furniture, fixtures and other		5 years
Laboratory equipment		7 years
Leasehold improvements		Shorter of the useful life of asset or the lease term

Leases

Leases

The Company enters into contracts in the normal course of business and assesses whether any such contracts contain a lease. The Company determines if an arrangement is a lease at inception if it conveys the right to control the identified asset for a period of time in exchange for consideration. Under ASC 842, lease expense is recognized as a single lease cost on a straight-line basis over the lease term. The lease term consists of non-cancelable periods and may include options to extend or terminate the lease term, when it is reasonably certain such options will be exercised.

Leases classified as operating leases are included in operating lease right-of-use, or ROU, assets, current operating lease liabilities and noncurrent operating lease liabilities in our consolidated balance sheet. Finance leases are included in property and equipment and finance lease obligations, in our consolidated balance sheet. ROU assets represent the right to use an underlying asset for the lease term. Lease liabilities represent the present value of future lease payments, net of lease incentives, discounted using an incremental borrowing rate, which is a management estimate based on the information available at the commencement date of a lease arrangement. ROU assets and lease liabilities are recognized at the lease commencement date.

The Company has elected to account for the lease and non-lease components for leases as a single component for classes of all underlying assets and allocate all the contract consideration to the lease component only. Lease cost for operating leases is recognized on a straight-line basis over the lease term and is included in operating expenses on the statements of operations and comprehensive loss. Variable lease payments are included in lease operating expenses.

The Company recognizes costs associated with lease arrangements having an initial term of 12 months or less, or short-term leases, on a straight-line basis over the lease term; such short-term leases are not recorded on the balance sheet.

Impairment of Long-Lived Assets

Impairment of Long-Lived Assets

Long-lived assets are reviewed for impairment whenever events or changes in circumstances indicate that the carrying amount of the asset or asset group may not be recoverable or that the useful life is shorter than originally estimated. When such events occur, the Company compares the carrying amounts of the asset or asset group to the undiscounted expected future cash flows. If this comparison indicates that the asset or asset group is impaired, the amount of impairment is measured as the difference between the carrying value and fair value of the asset or asset group. If the useful life is shorter than originally estimated, the Company will amortize the remaining carrying value over the new shorter useful life. To date, no such impairment loss has been recognized.

Segment Information

Segment Information

The Company identifies its operating segments in accordance with Accounting Standards Codification 280, Segment Reporting, or ASC 280. Operating segments are defined as components of an enterprise about which separate discrete financial information is available for evaluation by the chief operating decision maker, or decision-making group, in deciding how to allocate resources and in assessing performance. The Company’s chief operating decision maker, its Chief Executive Officer, manages the Company’s operations on a consolidated basis for the purposes of allocating resources. Accordingly, the Company has determined it operates and manages its business in a single reportable operating segment.

Goodwill

Goodwill

Goodwill represented the excess of purchase price over the fair value of identifiable net assets acquired in a business combination. Goodwill has an indefinite useful life. Goodwill was assessed annually for impairment as of December 31, or more frequently if an event occurs or circumstances change that would indicate that it is more likely than not that the fair value of a reporting unit or the fair value of an indefinite-lived intangible asset has declined below its carrying value. In performing its annual goodwill impairment assessment, the Company has the option under GAAP to qualitatively assess whether it is more likely than not that the fair value of a reporting unit is less than its carrying value; if the conclusion of the qualitative assessment is that there are no indicators of impairment, the Company does not perform a quantitative assessment. Otherwise, a quantitative assessment is performed and the fair value of the reporting unit is determined.

Goodwill was evaluated for impairment at the reporting unit level, which is defined as an operating segment, or one level below an operating segment. The Company has determined that it operates as one reporting unit and has selected December 31 as the date to perform its annual impairment test.

As of December 31, 2022, the Company elected to forego the qualitative screen and performed a quantitative annual goodwill impairment test for the reporting unit.

As of December 31, 2022, the Company’s stock price and market capitalization declined 60% from December 31, 2021, which reflected the overall decline of similar companies with less than $250 million in market capitalizations, or microcap companies. The life sciences sector, which includes pre-commercialization and therefore net operating loss generating companies, relied heavily on the capital markets to finance their operations and fund pre-clinical and clinical trials for their existing development programs. As a result of a shift in risk appetite in the overall financial markets, the availability of capital for life science sector companies decreased significantly in 2022. The challenging financing conditions had a negative impact on stock prices and respective market capitalizations, particularly for microcap companies. The Company considered the heightened financing risk that impacted the life sciences sector during 2022 to be one of the key macroeconomic factors that led to a sustained decrease in the Company’s stock price and market capitalization leading up to its annual goodwill impairment assessment date in late 2022.

Based upon the results of its 2022 annual goodwill impairment test, the Company recorded a loss on impairment of goodwill of $29.5 million during the year ended December 31, 2022, resulting in full impairment of goodwill.

The following table provides a roll forward of the Company’s goodwill and accumulated impairment losses:

	Goodwill
Goodwill, gross amount as of January 1, 2022	$	29,517
Loss on impairment		(29,517	)
Goodwill as of December 31, 2022	$	-

Research and Development

Research and Development

Research and development expenses consist primarily of third-party costs incurred to develop drug candidates, personnel-related expenses, including salaries, benefits, travel and stock-based compensation expense, depreciation and other allocated overhead costs, which include rent and maintenance of facilities and other supplies. Research and development costs are expensed as incurred.

Before a compound receives regulatory approval, the Company records upfront and milestone payments made to third parties under licensing arrangements as expense provided that there is no alternative future use of the rights in other research and development projects.

Nonrefundable advance payments to vendors for goods or services that will be used or received in future research and development activities are deferred and recognized as expense in the period in which the related goods are delivered or services are performed. Where milestone payments are due to third parties under research and development collaboration arrangements or other contractual agreements, the milestone payment obligations are expensed when the milestone conditions are met and the amount of payment is reasonably estimable.

Once a compound receives regulatory approval, the Company records any milestone payments in identifiable intangible assets, less accumulated amortization and, unless the asset is determined to have an indefinite life, the Company amortizes the payments on a straight-line basis over the remaining agreement term or the expected product life cycle, whichever is shorter.

Certain third-party costs are included as a component of research and development expense. These expenses include fees paid to contract research organizations, or CROs, and other clinical trial costs, contractual services costs and costs for supply of its drug candidates. Depending upon the timing of payments to the service providers, the Company recognizes prepaid expenses or accrued expenses related to these costs. These accrued or prepaid expenses are based on management’s estimates of the work performed under service agreements, milestones achieved and experience with similar contracts in conjunction with known variable factors such as enrolled patients and site activity. The Company monitors each of these factors and adjusts estimates accordingly.

Patent Costs

Patent Costs

All patent-related costs incurred in connection with filing and prosecuting patent applications are expensed as incurred due to the uncertainty about the recovery of the expenditure. Amounts incurred are classified as general and administrative expenses.

Interest and Investment Income

Interest and Investment Income

Investment income consists primarily of interest income, accretion income earned and amortization expense incurred and realized gains or losses related to our marketable debt securities, interest income related to cash, cash equivalents and restricted cash and dividend income related to money market funds.

Stock-Based Compensation

Stock-Based Compensation

The Company’s stock-based compensation programs include stock options, restricted stock units, or RSUs, and an employee stock purchase program, or ESPP. The Company accounts for stock-based compensation using the fair value method.

The Company measures all stock options and other stock-based awards granted to employees and directors based on the fair value on the date of the grant and recognizes compensation expense of those awards over the requisite service period, which is generally the vesting period of the respective award. The Company recognizes forfeitures at the time forfeitures occur.

The fair value of each option is estimated on the date of grant using the Black-Scholes option-pricing model. Expected volatility for the Company’s common stock is determined based on an average of the historical volatility of the Company and the historical volatility of a peer-group of similar public companies. The expected term of options granted to employees is calculated using the simplified method, which represents the average of the contractual term of the option and the weighted-average vesting period of the option. The simplified method is used as the Company does not have sufficient appropriate exercise data on which to base its own estimate. The assumed dividend yield is based upon the Company’s expectation of not paying dividends in the foreseeable future. The risk-free interest rate is based upon the U.S. Treasury yield curve commensurate with the expected term at the time of grant or remeasurement.

The stock-based compensation expense associated with purchase rights under the ESPP is measured at fair-value using a Black-Scholes option-pricing model at commencement of each offering period and recognized over that offering period. The Black-Scholes option pricing assumptions are similar to those used for stock options with the exception of the expected term of purchase rights for the ESPP which is based on the duration of an offering period.

The fair values of RSUs are based on the fair market value of the Company’s common stock on the date of the grant.

The RSUs are granted to directors pursuant to the Company’s equity plan. Settlement for the RSUs is deferred until the earliest to occur of (i) the director’s termination of service, (ii) death, (iii) disability or (iv) a change in control of the Company. In the event of a change in control of the Company, the RSUs will vest in full.

The fair value of all stock-based awards is recognized as stock-based compensation expense on a straight-line basis over the vesting period, which is typically one to four years for RSUs and four years for stock options.

The Company classifies stock-based compensation expense in its statement of operations and comprehensive loss in the same way the payroll costs or service payments are classified for the related stock-based award recipients.

Income Taxes

Income Taxes

Deferred tax assets and liabilities are recognized for the estimated future tax consequences attributable to differences between the financial statement carrying amounts of existing assets and liabilities and their respective tax basis, operating loss and tax credit carryforwards. Deferred tax assets and liabilities are measured using enacted tax rates in effect for the year in which those temporary differences are expected to be recovered or settled. The measurement of net deferred tax assets is reduced by the amount of any tax benefit that, based on available evidence, is not expected to be realized, and a corresponding valuation allowance is established. In making such a determination, the Company considers all available positive and negative evidence, including future reversals of existing taxable temporary differences, projected future taxable income, tax-planning strategies, and results of recent operations.

Tax benefits are recognized only for tax positions that are more likely than not to be sustained upon examination by tax authorities. The amount recognized is measured as the largest amount of benefit that is greater than 50 percent likely to be realized upon settlement. A liability for unrecognized tax benefits is recorded for any tax benefits claimed in the Company’s tax returns that do not meet these recognition and measurement standards. The Company’s policy is to record interest and penalties on uncertain tax positions as a component of income tax expense in the consolidated statement of operations and comprehensive loss.

Net Loss Per Share Attributable to Common Stockholders

Net Loss Per Share Attributable to Common Stockholders

Basic net loss per share is computed by dividing the net loss attributable to common stockholders by the weighted-average number of shares of common stock outstanding during the period. Diluted net loss per share is computed by dividing net loss attributable to common stockholders by the weighted-average number of shares of common stock outstanding during the period plus the common equivalent shares for the period including any dilutive effect from unvested restricted common stock, outstanding stock options and potential shares issuable under the ESPP.

Recently Adopted Accounting Pronouncements

Recently Adopted Accounting Pronouncements

In June 2016, the Financial Accounting Standards Board, or the FASB, issued ASU 2016-13 - Measurement of Credit Losses on Financial Statements. The new standard requires that expected credit losses relating to financial assets measured on an amortized cost basis and available-for-sale debt securities be recorded through an allowance for credit losses. It also limits the amount of credit losses to be recognized for available-for-sale debt securities to the amount by which carrying value exceeds fair value and also requires the reversal of previously recognized credit losses if fair value increases. In November 2019, the FASB issued ASU 2019-10 – Financial Instruments – Credit Losses (Topic 326), Derivatives and Hedging (Topic 815), and Leases (Topic 842): Effective Dates, which amended the effective date for certain companies. The standard is effective for public companies eligible to be smaller reporting companies for annual and interim periods beginning after December 15, 2022. On January 1, 2023, the Company adopted ASU 2016-13, using a modified retrospective approach. The adoption of this standard did not have an effect on the Company’s consolidated financial position, results of operations, or cash flows.

Recent Accounting Pronouncements Not Yet Adopted

Recent Accounting Pronouncements Not Yet Adopted

The Company has evaluated other recently issued accounting pronouncements and has concluded that the impact of recently issued standards that are not yet effective will not have a material impact on the Company’s financial position or results of operations upon adoption.

Subsequent Events

Subsequent Events

The Company evaluated subsequent events and transactions that occurred after the balance sheet date up to the date that the financial statements were available to be issued. Other than as described in Note 12 and, the Company did not identify any subsequent events that would have required adjustment or disclosure in the financial statements.

Accrued Expenses (Tables)

12 Months Ended

Dec. 31, 2023

Accrued Expenses [Abstract]

Schedule of Accrued Expenses

Accrued expenses consist of the following as of:

	December 31,
	2023		2022
Employee costs	$	2,112	$	2,543
Research and development		440		512
Other expenses		180		182
Total	$	2,732	$	3,237

Fair Value of Financial Instruments (Details) - Schedule of Financial Assets and Liabilities that are Measured and Carried at Fair Value - USD ($)
$ in Thousands

Dec. 31, 2023

Dec. 31, 2022

Cash equivalents:

Money market funds

^[1]

$ 39,031

$ 13,284

Corporate bonds

^[1]

2,523

Restricted cash, non-current:

Money market funds

^[2]

745

Marketable debt securities:

Corporate bonds

^[3]

23,495

78,129

Agency bonds

^[3]

2,499

Total

65,770

94,681

Level 1 [Member]

Cash equivalents:

Money market funds

^[1]

39,031

13,284

Corporate bonds

^[1]

Restricted cash, non-current:

Money market funds

^[2]

745

Marketable debt securities:

Corporate bonds

^[3]

Agency bonds

^[3]

Total

39,776

14,029

Level 2 [Member]

Cash equivalents:

Money market funds

^[1]

Corporate bonds

^[1]

2,523

Restricted cash, non-current:

Money market funds

^[2]

Marketable debt securities:

Corporate bonds

^[3]

23,495

78,129

Agency bonds

^[3]

2,499

Total

25,994

80,652

Level 3 [Member]

Cash equivalents:

Money market funds

^[1]

Corporate bonds

^[1]

Restricted cash, non-current:

Money market funds

^[2]

Marketable debt securities:

Corporate bonds

^[3]

Agency bonds

^[3]

Total

[1]	Money market funds and bonds with original maturities of 90 days or less are included within Cash and cash equivalents in the consolidated balance sheets.
[2]	Restricted Money market funds are included within Restricted Cash, non-current in the consolidated balance sheets.
[3]	Bonds with original maturities greater than 90 days are included within Marketable debt securities in the consolidated balance sheets and classified as current or noncurrent based upon whether the maturity of the financial asset is less than or greater than 12 months.

Leases

12 Months Ended

Dec. 31, 2023

Leases [Abstract]

Leases

9. Leases

Operating leases

In December 2020, the Company entered into an agreement to lease approximately 10,300 square feet of office space in New York, New York, the Office Lease, which commenced in April 2021. Annual rent is approximately $1,117. The Office Lease has a term of approximately seven years and contains provisions for a free-rent period, annual rent increases and an allowance for tenant improvements. The Company has an option to extend the term by five years, however, the Company determined at the lease commencement date that it was not reasonably certain to exercise the renewal option and such renewal was excluded from the operating lease right-of-use, or ROU, asset and operating lease liability recorded for this lease.

The Company is responsible for real estate taxes, maintenance and other operating expenses applicable to the leased premises which are recognized as variable lease expense in the period when incurred. In conjunction with the Office Lease, the Company established a letter of credit of approximately $745 secured by cash balances included in restricted cash, non-current, within the consolidated balance sheets.

In June 2021, the Company amended the existing agreement with its contract development and manufacturing organization, or CDMO, establishing a term of eight-years from the amendment date.

Leases classified as operating leases are included in operating lease right-of-use, or ROU, assets, operating lease liabilities and operating lease liabilities, non-current, in the Company’s consolidated balance sheets. The Office Lease and the CDMO leased spaces are included in operating lease ROU assets and operating lease liabilities within the consolidated balance sheets. Cash paid for operating lease liabilities was $1,234 and $1,327 during the years ended December 31, 2023 and 2022, respectively.

The components of lease expense were as follows:

	For the year ended December 31,
Lease expense	2023		2022
Operating lease expense	$	1,423	$	1,366
Short-term lease expense		-		3
Total	$	1,423	$	1,369

Variable lease expense for the years ended December 31, 2023 and 2022, respectively was not material.

The weighted average remaining lease term and the weighted average discount rate for operating leases were:

	For the year ended December 31,
	2023			2022

Weighted-average discount rate		7.0	%		7.0	%
Weighted-average remaining lease term – operating lease (in months)		55			67

The total remaining operating lease payments included in the measurement of lease liabilities on the Company’s consolidated balance sheet as of December 31, 2023, was as follows:

For the year ending December 31:	Operating Lease Payments
2024	$	1,327
2025		1,395
2026		1,429
2027		1,429
2028		718
Thereafter		87
Total future operating lease payments		6,385
Less: imputed interest		(918	)
Present value of future minimum lease payments	$	5,467

Fair Value of Financial Instruments (Details) $ in Millions	12 Months Ended
Fair Value of Financial Instruments (Details) $ in Millions	Dec. 31, 2023 USD ($)
Non-Recurring Fair Value Measurements [Member]
Fair Value of Financial Instruments [Line Items]
Goodwill impairment loss	$ 29.5

Stock-Based Compensation (Details) - Schedule of Restricted Stock Unit Activity - Restricted stock unit [Member]	12 Months Ended
	Dec. 31, 2023 $ / shares shares
Stock-Based Compensation [Line Items]
Restricted Stock Units, Balance at beginning \| shares	196,838
Weighted Average Grant Date Fair Value, Balance at beginning \| $ / shares	$ 12.49
Restricted Stock Units, Granted \| shares	165,100
Weighted Average Grant Date Fair Value, Granted \| $ / shares	$ 3.02
Restricted Stock Units, Forfeited \| shares	(30,731)
Weighted Average Grant Date Fair Value, Forfeited \| $ / shares	$ 4.35
Restricted Stock Units, Vested \| shares	(94,528)
Weighted Average Grant Date Fair Value, Vested \| $ / shares	$ 12.16
Restricted Stock Units, Balance at ending \| shares	236,679
Weighted Average Grant Date Fair Value, Balance at ending \| $ / shares	$ 7.07

Audit Information	12 Months Ended
Audit Information	Dec. 31, 2023
Auditor [Table]
Auditor Name	Ernst & Young LLP
Auditor Firm ID	42
Auditor Location	New York, New York

Commitments and Contingencies

12 Months Ended

Dec. 31, 2023

Commitments and Contingencies [Abstract]

Commitments and Contingencies

10. Commitments and Contingencies

Employment Agreements

Executive Employment Agreements

The Company’s executive officers have entered into at-will employment agreements.

Collaborations and License Agreements

Choline License Agreement

On September 27, 2017, the Company entered into a license agreement, or the Choline License Agreement, with Alan L. Buchman, or Dr. Buchman. Pursuant to the Choline License Agreement, the Company received from Dr. Buchman the license rights in and to the “Licensed Orphan Designations”, the “Licensed IND”, “Existing Study Data” and the “Licensed Know-How” for one or more of the licensed indications.

Certain milestone and royalty payments may also be payable to Dr. Buchman. Regardless of whether development or commercialization is undertaken by the Company under the Choline License Agreement, during the term of the Choline License Agreement, the Company shall pay Dr. Buchman a minimum annual royalty that ranges from $25 to $75. The Company will also pay Dr. Buchman up to $775 in additional milestone payments upon the achievement of various regulatory approval milestones. Further, the Company agreed to sales royalties described further in Item 1. Business.

During the years ended December 31, 2023 and 2022, the Company recorded research and development expense of $27 and $2, in connection with the Choline License Agreement.

License Agreement

On December 22, 2017, the Company entered into an agreement, or the Feinstein Agreement, with The Feinstein Institute for Medical Research, or the Feinstein Institute, a not-for-profit corporation with 50 research labs and 2,500 clinical research studies. Pursuant to the Feinstein Agreement, the Company acquired an exclusive license relating to treatment of fatty liver diseases in humans for which Choline may be an effective therapeutic. In consideration for the rights and license granted, the Feinstein Institute would receive a royalty of one percent (1%) of the first one hundred million dollars ($100,000) of net sales of IV Choline Chloride and a royalty of one and one-half percent (1.5%) of all net sales thereafter. In addition, the Company would pay the Feinstein Institute twelve and one-half percent (12.5%) of net proceeds resulting from agreements entered within 2 years from the effective date, and seven and one-half percent (7.5%) of net proceeds resulting from agreements entered into thereafter. Pursuant to the Feinstein Agreement additional payments would be due to the Feinstein Institute for license maintenance payments and for meeting milestone events. Pursuant to the Feinstein Agreement, upon the achievement of certain future new drug application milestones, the Company would be obligated to remit an aggregate of $275.

During the years ended December 31, 2023 and 2022, the Company recorded research and development expense of $15 and $17, respectively, in connection with the Feinstein Agreement.

Sponsored Research and License Agreement

On November 28, 2018, the Company entered into a sponsored research and license agreement, or the Iowa Agreement, with the University of Iowa. Pursuant to the Iowa Agreement, the University of Iowa, which is engaged in clinical research to improve the diagnosis and treatment of lymphangioma using a pharmaceutical product (OK-432), would assist the Company in collecting case reports, forms, source data, and safety data available to the University of Iowa in support of the development of the Company’s proprietary Streptococcus Pyogenes investigational product, TARA-002 for the LMs indication. During the term of the services, the Company would generally pay the University of Iowa thirty thousand dollars ($30) per year to fund the project, plus additional amounts upon the realization of certain milestones. More specifically, upon forty-five (45) days of an approval of TARA-002 by the FDA, the Company would pay up to $1,750 to the University of Iowa for meeting these milestones. Furthermore, the Company would pay the University of Iowa royalties of up to 1.75% for net sales ranging from $0 - $25,000, 2.25% for net sales ranging from $25,000 to $50,000, and 2.50% for net sales in excess of $50,000. Pursuant to the Iowa Agreement, the University of Iowa would be entitled to additional payments for the Company achieving annual net sales of product according to the milestones. For annual net sales of product up to $25,000: $62; for annual net sales of product of up to $50,000: $62; and for annual net sales of product of up to $100,000: $125.

Pursuant to the Iowa Agreement there were no research and development expenses recognized during the years ended December 31, 2023 and 2022.

Chugai Agreement

On June 17, 2019, the Company entered into an agreement, or the Chugai Pharmaceutical Agreement, with Chugai Pharmaceutical Co., LTD, or Chugai, a drug manufacturing firm with offices and operations in Japan. Pursuant to the Chugai Pharmaceutical Agreement, Chugai would help the Company in its goals to develop and commercialize a therapeutic product, or the New Product, which is comparable to the Chugai existing therapeutic product, or the Existing Product. In addition, the Company would be entitled to the use of Chugai materials and technical support as necessary. On July 14, 2020, the Company and Chugai entered into an amendment, or Chugai Amendment, to the Chugai Pharmaceutical Agreement, with an effective date of June 30, 2020. The Chugai Amendment extended the date through which Chugai will exclusively provide the Existing Product and materials to the Company from June 30, 2020 to June 30, 2021, extended the date through which Chugai will not provide materials or technical support to any third-party for the purpose of development and commercialization in a given area from the fifth anniversary to the eleventh anniversary of the original effective date, and provides for further such extensions on the occurrence of certain events and milestones. The amendment further provides that, in addition to the designated fee provided upon the initial indication approval in the Chugai Pharmaceutical Agreement, the Company will pay Chugai a designated fee for each additional indication approval. The Company is obligated to Chugai for certain payments upon the completion of agreed upon milestones. As consideration for Chugai’s performance under the Chugai Pharmaceutical Agreement, the Company agreed to pay Chugai a payment in the low, single-digit millions related to such initial indication approval, which payment will be made in two installments with an initial payment in July 2020, and the remaining majority of the payment payable upon FDA approval of the New Product.

Pursuant to the agreement there were no research and development expenses recognized during the years ended December 31, 2023 and 2022.

Contingencies

From time to time, the Company may be subject to various legal proceedings and claims that arise in the ordinary course of its business activities. Management is of the opinion that the ultimate outcome of these matters would not have a material adverse impact on the financial position of the Company or the results of its operations.

In the normal course of business, the Company enters into contracts in which it makes representations and warranties regarding the performance of its services and that its services will not infringe on third-party intellectual rights. There have been no significant events related to such representations and warranties in which the Company believes the outcome could result in losses or penalties in the future.

Income Taxes (Details) - Schedule of Federal and State Income Tax Expense - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Current
Federal
State
Total current
Deferred
Federal	(9,627)	(7,954)
State	(4,124)	(1,068)
Total deferred	(13,751)	(9,022)
Change in valuation allowance	13,751	9,022
Total income tax expense (benefit)

Insider Trading Arrangements	3 Months Ended
Insider Trading Arrangements	Dec. 31, 2023
Trading Arrangements, by Individual
Rule 10b5-1 Arrangement Adopted	false
Non-Rule 10b5-1 Arrangement Adopted	false
Rule 10b5-1 Arrangement Terminated	false
Non-Rule 10b5-1 Arrangement Terminated	false

Consolidated Statements of Operations and Comprehensive Loss (Parentheticals) - $ / shares	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Income Statement [Abstract]
Net loss per share attributable to common stockholders, diluted	$ (3.57)	$ (5.86)
Weighted average shares outstanding, diluted	11,331,338	11,259,615

- Definition

+ References

+ Details

Income Taxes (Details) - Schedule of Deferred Tax Assets and Liabilities - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Deferred tax assets:
Net operating loss carry forwards	$ 30,731	$ 26,768
Capitalized research and development	9,611	3,418
Stock option expense	4,464	2,477
Research and development credits	4,824	3,710
Operating lease liability	1,485	1,481
RSU expense	2,723	2,199
Other	467	408
Total deferred tax assets	54,305	40,461
Valuation allowance	(52,734)	(38,983)
Deferred tax assets, net of valuation allowance	1,571	1,478
Deferred tax liabilities:
Operating right-of-use asset	(1,430)	(1,456)
Other	(141)	(22)
Total deferred tax liabilities	(1,571)	(1,478)
Deferred tax assets, net of valuation allowance and deferred tax liabilities

Consolidated Balance Sheets (Parentheticals) - $ / shares	Dec. 31, 2023	Dec. 31, 2022
Preferred stock, par value (in Dollars per share)	$ 0.001	$ 0.001
Preferred stock, shares authorized	10,000,000	10,000,000
Common stock, par value (in Dollars per share)	$ 0.001	$ 0.001
Common stock, shares authorized	100,000,000	100,000,000
Common stock, shares issued	11,364,903	11,267,389
Common stock, shares outstanding	11,364,903	11,267,389
Series 1 Convertible Preferred Stock
Preferred stock, shares authorized	8,028	8,028
Preferred stock, shares issued	7,991	8,027
Preferred stock, shares outstanding	7,991	8,027

Stock-Based Compensation (Tables)

12 Months Ended

Dec. 31, 2023

Stock-Based Compensation [Abstract]

Schedule of Restricted Stock Unit Activity

The following table summarizes restricted stock unit activity:

	Restricted Stock Units			Weighted Average Grant Date Fair Value
Non-vested at December 31, 2022		196,838		$	12.49
Granted		165,100			3.02
Forfeited		(30,731	)		4.35
Vested		(94,528	)		12.16
Non-vested at December 31, 2023		236,679		$	7.07

Schedule of the Fair Value of Stock Options Granted

The Company determined the fair value of stock options granted utilizing the Black-Scholes valuation model and based upon the assumptions as provided below:

	For the Years Ended December 31,
	2023			2022
Exercise price		$1.20 - $3.91			$2.77 - $6.90
Dividend yield		0.00	%		0.00	%
Expected volatility		90.00% - 98.00	%		92.00% - 99.00	%
Risk-free interest rate		3.46% - 4.73	%		1.46% - 4.23	%
Expected life (in years)		5.27 - 6.08			5.27 - 6.08

Schedule of Stock Option Activities

The following table summarizes stock option activities for the year ended December 31, 2023:

	Number of Options			Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (years)		Aggregate Intrinsic Value (1)
Outstanding at December 31, 2022		1,828,329		$	14.23		8.16	$	-
Granted		1,310,900			2.99
Exercised		-			-
Forfeited		(157,523	)		6.83
Expired		(81,501	)		15.94
Outstanding at December 31, 2023		2,900,205		$	9.50		8.03	$	20

Vested or expected to vest at December 31, 2023		2,900,205		$	9.50		8.03	$	20
Exercisable as of December, 31 2023		1,242,111		$	15.48		7.08	$	-

(1)

Aggregate intrinsic value represents the difference between the exercise price of the option and the closing market price of our common stock on December 31, 2023. The intrinsic value of options exercised during the years ended December 31, 2023 and 2022 was $0 and no options were exercised.

Schedule of Total Stock-Based Compensation Costs

The following tables summarize total stock-based compensation costs recognized:

	For the Years Ended December 31,
	2023		2022
RSUs	$	1,208	$	1,272
Stock options		4,884		5,416
Total	$	6,092	$	6,688

Schedule of Stock-Based Compensation Expense

Stock-based compensation expense was reflected within the consolidated statements of operations and comprehensive loss:

	For the Years Ended December 31,
	2023		2022
Research and development	$	1,653	$	1,511
General and administrative		4,439		5,177
Total	$	6,092	$	6,688

Income Taxes

12 Months Ended

Dec. 31, 2023

Income Taxes [Abstract]

Income Taxes

13. Income Taxes

Federal and State income tax expense is as follows:

	For the Years Ended December 31,
	2023			2022
Current
Federal	$	-		$	-
State		-			-
Total current		-			-
Deferred
Federal		(9,627	)		(7,954	)
State		(4,124	)		(1,068	)
Total deferred		(13,751	)		(9,022	)
Change in valuation allowance		13,751			9,022
Total income tax expense (benefit)	$	-		$	-

Deferred income taxes, if applicable, are provided for the differences between the basis of assets and liabilities for financial reporting and income tax purposes.

The tax effects of temporary differences that give rise to significant portions of the deferred tax assets are as follows:

	As of December 31,
	2023			2022
Deferred tax assets:
Net operating loss carry forwards	$	30,731		$	26,768
Capitalized research and development		9,611			3,418
Stock option expense		4,464			2,477
Research and development credits		4,824			3,710
Operating lease liability		1,485			1,481
RSU expense		2,723			2,199
Other		467			408
Total deferred tax assets		54,305			40,461
Valuation allowance		(52,734	)		(38,983	)
Deferred tax assets, net of valuation allowance		1,571			1,478
Deferred tax liabilities:
Operating right-of-use asset		(1,430	)		(1,456	)
Other		(141	)		(22	)
Total deferred tax liabilities		(1,571	)		(1,478	)
Deferred tax assets, net of valuation allowance and deferred tax liabilities	$	-		$	-

A reconciliation of the provision for income taxes with the amounts computed by applying the statutory Federal income tax to income before provision for income taxes is as follows:

	For the Years Ended December 31,
	2023			2022
U.S. federal statutory rate		(21.0	)%		(21.0	)%
State taxes, net of federal benefit		(7.8	)%		(2.2	)%
State rate change		(4.0	)%		-	%
Research and development credits		(2.4	)%		(3.3	)%
True-up to prior years return		2.2	%		(0.7	)%
Stock-based compensation		(1.3	)%		0.1	%
Other		0.4	%		(0.3	)%
Goodwill impairment		-	%		10.4	%
Change in valuation allowance		33.9	%		17.0	%
Effective tax rate		-	%		-	%

For the year ended December 31, 2023, the Company’s effective tax rate was 0%, which consisted principally of a federal rate of 21%, and the Company’s estimate of state taxes, net of federal benefit, of 7.8%, as well as state tax rate and apportionment changes of 4.0%, which collectively are offset by a valuation allowance 33.9%. For the year ended December 31, 2022, the Company’s effective tax rate was 0%, which consisted principally of a federal rate of 21%, the Company’s estimate of state taxes, net of federal benefit, of 2.2%, research and development credits of 3.3% and a true-up to the prior year’s tax return of 0.7%, offset by goodwill impairment of 10.4% and a valuation allowance 17.0%.

As of December 31, 2023 and 2022 for U.S. federal and state income tax reporting purposes, the Company has approximately $187,492 and $114,800, respectively, of unused net operating losses, or NOLs, available for carry forward to future years. As a result of the Tax Cuts and Jobs Act of 2017, or TCJA, for U.S. income tax purposes, NOLs generated in tax years beginning before January 1, 2018 can still be carried forward for up to 20 years, but net operating losses generated for tax years beginning after December 31, 2017 carryforward indefinitely and can be used to offset taxable income. Of the total Federal NOL, $600 can be carried forward until 2037; and $128,196 can be carried forward indefinitely. The New York state and city NOLs may be carried forward through the year 2043 and may be applied against future taxable income. Further, the benefit from utilization of NOL carry forwards could be subject to limitations due to material ownership changes that could occur as the Company continues to issue additional shares of common stock pursuant to its capital raising plans. Based on such limitations, the Company has significant NOLs for which realization of tax benefits is uncertain. The Company has not performed a study to determine whether or not there is such a limitation.

The Company remains subject to examination by tax authorities for all tax years.

Based on a history of cumulative losses at the Company and the results of operations for the years ended December 31, 2023 and 2022, the Company determined that it is more likely than not that it will not realize benefits from the net deferred tax assets. The Company will not record income tax benefits in the financial statements until it is determined that it is more likely than not that the Company will generate sufficient taxable income to realize the deferred income tax assets. As a result of the analysis, the Company determined that a full valuation allowance against the deferred tax assets, net, was required. As of December 31, 2023 and 2022, the Company has recorded a valuation allowance of $52.7 million and $39.0 million, respectively.

As of December 31, 2023 and 2022, management does not believe that the Company has any material uncertain tax positions that would require it to measure and reflect the potential lack of sustainability of a position on audit in its consolidated financial statements. The Company will continue to evaluate its uncertain tax positions in future periods to determine if measurement and recognition in its financial statements is necessary. The Company does not believe there will be any material changes in its unrecognized tax positions over the next year.

- Definition

The entire disclosure for income taxes. Disclosures may include net deferred tax liability or asset recognized in an enterprise's statement of financial position, net change during the year in the total valuation allowance, approximate tax effect of each type of temporary difference and carryforward that gives rise to a significant portion of deferred tax liabilities and deferred tax assets, utilization of a tax carryback, and tax uncertainties information.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 946
-SubTopic 20
-Name Accounting Standards Codification
-Section 50
-Paragraph 13
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-URI https://asc.fasb.org//1943274/2147480990/946-20-50-13

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 235
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-Paragraph 1
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Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-Name Accounting Standards Codification
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Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-SubTopic 10
-Name Accounting Standards Codification
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-Paragraph 14
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482685/740-10-50-14

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
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-Paragraph 21
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-URI https://asc.fasb.org//1943274/2147482685/740-10-50-21

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
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Reference 7: http://www.xbrl.org/2003/role/disclosureRef
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Reference 8: http://www.xbrl.org/2003/role/disclosureRef
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-Publisher FASB
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Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-SubTopic 10
-Name Accounting Standards Codification
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Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-SubTopic 30
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482603/740-30-50-2

+ Details

Income Taxes (Details) - Schedule of Federal Income Tax to Income Before Provision for Income Taxes - Federal Income Tax [Member]	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Schedule of Federal Income Tax to Income Before Provision for Income Taxes [Line Items]
U.S. federal statutory rate	(21.00%)	(21.00%)
State taxes, net of federal benefit	(7.80%)	(2.20%)
State rate change	(4.00%)
Research and development credits	(2.40%)	(3.30%)
True-up to prior years return	2.20%	(0.70%)
Stock-based compensation	(1.30%)	0.10%
Other	0.40%	(0.30%)
Goodwill impairment		10.40%
Change in valuation allowance	33.90%	17.00%
Effective tax rate

Summary of Significant Accounting Policies

12 Months Ended

Dec. 31, 2023

Summary of Significant Accounting Policies [Abstract]

Summary of Significant Accounting Policies

2. Summary of Significant Accounting Policies

Basis of Presentation

The accompanying consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“U.S. GAAP” or “GAAP”).

Principles of Consolidation

Use of Estimates

Cash, Cash Equivalents and Restricted Cash

The following table provides a reconciliation of cash, cash equivalents, and restricted cash in the consolidated balance sheets to the total amount shown in the consolidated statements of cash flows:

	December 31,
	2023		2022
Cash and cash equivalents	$	39,586	$	24,127
Restricted cash, non-current		745		745
Total cash, cash equivalents and restricted cash shown in the consolidated statements of cash flows	$	40,331	$	24,872

Fair Value Measurements

●

Level 1 Quoted prices in active markets for identical assets or liabilities.

●

Level 3 Significant unobservable inputs that cannot be corroborated by market data.

The carrying amounts of cash and cash equivalents, prepaid expenses and accounts payable approximate their fair values due to the short-term nature of these instruments.

Marketable Debt Securities

Concentrations of Credit Risk

Financial instruments, which potentially subject the Company to concentrations of credit risk, consists principally of cash, cash equivalents, restricted cash, and marketable debt securities.

Property and Equipment, net

The estimated useful lives for significant property and equipment categories are as follows:

Asset Classification		Estimated Useful Life
Computer equipment		3-5 years
Furniture, fixtures and other		5 years
Laboratory equipment		7 years
Leasehold improvements		Shorter of the useful life of asset or the lease term

Leases

Impairment of Long-Lived Assets

Segment Information

Goodwill

As of December 31, 2022, the Company elected to forego the qualitative screen and performed a quantitative annual goodwill impairment test for the reporting unit.

The following table provides a roll forward of the Company’s goodwill and accumulated impairment losses:

	Goodwill
Goodwill, gross amount as of January 1, 2022	$	29,517
Loss on impairment		(29,517	)
Goodwill as of December 31, 2022	$	-

Research and Development

Patent Costs

Interest and Investment Income

Stock-Based Compensation

The fair values of RSUs are based on the fair market value of the Company’s common stock on the date of the grant.

Income Taxes

Net Loss Per Share Attributable to Common Stockholders

Recently Adopted Accounting Pronouncements

Recent Accounting Pronouncements Not Yet Adopted

Subsequent Events

Stock-Based Compensation (Details) - Schedule of Stock-Based Compensation Expense - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Total stock-based compensation	$ 6,092	$ 6,688
Research and development [Member]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Total stock-based compensation	1,653	1,511
General and administrative [Member]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Total stock-based compensation	$ 4,439	$ 5,177

Stockholders’ Equity

12 Months Ended

Dec. 31, 2023

Stockholders’ Equity [Abstract]

Stockholders’ Equity

11. Stockholders’ Equity

Common Stock

As of December 31, 2023, the Company had 100,000,000 shares of common stock authorized for issuance, $0.001 par value per share, of which 11,364,903 and 11,267,389 shares were issued and outstanding as of December 31, 2023 and 2022, respectively.

The holders of the Company’s common stock are entitled to one vote per share.

Preferred Stock

As of December 31, 2023 and 2022, the Company had 10,000,000 shares of preferred stock authorized for issuance, $0.001 par value per share, of which 8,028 shares of Series 1 Convertible Preferred Stock are authorized for issuance. As of December 31, 2023 and 2022, 7,991 and 8,027 shares were issued and outstanding, respectively.

Description of Series 1 Convertible Preferred Stock

Each share of Series 1 Convertible Preferred Stock is convertible into approximately 1,000 shares of the Company’s common stock, at a conversion price initially equal to approximately $7.01 per common share, subject to adjustment for any stock splits, stock dividends and similar events, at any time at the option of the holder, provided that any conversion of Series 1 Convertible Preferred Stock by a holder into shares of the Company’s common stock would be prohibited if, as a result of such conversion, the holder, together with its affiliates and any other person or entity whose beneficial ownership of the Company’s common stock would be aggregated with such holder’s for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, would beneficially own more than 9.99% of the total number of shares of the Company’s common stock issued and outstanding after giving effect to such conversion. Upon written notice to the Company, the holder may from time to time increase or decrease such limitation to any other percentage not in excess of 19.99% specified in such notice. In addition, upon the occurrence of certain transactions that involve the merger or consolidation of the Company, an exchange or tender offer, a sale of all or substantially all of the assets of the Company or a reclassification of its Common Stock, each share of Series 1 Convertible Preferred Stock will be convertible into the kind and amount of securities, cash and/or other property that the holder of a number of shares of Common Stock issuable upon conversion of one share of Series 1 Convertible Preferred Stock would receive in connection with such transaction.

The terms of the Series 1 Convertible Preferred Stock provide that, in the event of a fundamental transaction (as such term is described in the certificate of designation of preferences, rights and limitations of series 1 convertible non-voting preferred stock), each share of Series 1 Convertible Preferred Stock outstanding will thereafter be convertible into the kind and amount of securities, cash and/or other property which a holder of the number of shares of Common Stock of the Company issuable upon conversion of one share of Series 1 Convertible Preferred Stock immediately prior to such fundamental transaction would have been entitled to receive pursuant to such fundamental transaction, provided that, if the value of the aggregate of such securities, cash and/or other property the which the holder of one share of Series 1 Convertible Preferred Stock would be entitled to upon conversion thereof would be less than the stated value, then each outstanding share of Series 1 Convertible Preferred Stock will instead be convertible into such kind of securities, cash and/or other property with an aggregate value equal to the stated value.

Each share of Series 1 Convertible Preferred Stock is entitled to a preference of $10.00 per share upon liquidation of the Company, and thereafter will share ratably in any distributions or payments on an as-converted basis with the holders of Common Stock.

The holders of Series 1 Convertible Preferred Stock are not entitled to vote.

During August 2023, approximately 36 shares of Series 1 Convertible Preferred Stock were converted into 35,823 shares of common stock.

- Definition

The entire disclosure for equity.

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+ Details

Pay vs Performance Disclosure - USD ($) $ in Thousands	12 Months Ended
Pay vs Performance Disclosure - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Pay vs Performance Disclosure
Net Income (Loss)	$ (40,420)	$ (65,952)

- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

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+ Details

Marketable Debt Securities (Details) - Schedule of Marketable Debt Securities in a Loss Position - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Security Owned Not Readily Marketable [Line Items]
Estimated Fair Value	$ 25,994	$ 78,129
Unrealized Losses	(31)	$ (688)
Corporate Bonds – Presented in Marketable Debt Securities [Member]
Security Owned Not Readily Marketable [Line Items]
Estimated Fair Value	23,495
Unrealized Losses	(30)
Agency Bonds – Presented in Marketable Debt Securities [Member]
Security Owned Not Readily Marketable [Line Items]
Estimated Fair Value	2,499
Unrealized Losses	(1)
In Continuous Loss Position Less Than Twelve Months [Member]
Security Owned Not Readily Marketable [Line Items]
Estimated Fair Value	21,997
Unrealized Losses	(28)
In Continuous Loss Position Less Than Twelve Months [Member] \| Corporate Bonds – Presented in Marketable Debt Securities [Member]
Security Owned Not Readily Marketable [Line Items]
Estimated Fair Value	19,498
Unrealized Losses	(27)
In Continuous Loss Position Less Than Twelve Months [Member] \| Agency Bonds – Presented in Marketable Debt Securities [Member]
Security Owned Not Readily Marketable [Line Items]
Estimated Fair Value	2,499
Unrealized Losses	(1)
In Continuous Loss Position Greater Than Twelve Months [Member]
Security Owned Not Readily Marketable [Line Items]
Estimated Fair Value	3,997
Unrealized Losses	(3)
In Continuous Loss Position Greater Than Twelve Months [Member] \| Corporate Bonds – Presented in Marketable Debt Securities [Member]
Security Owned Not Readily Marketable [Line Items]
Estimated Fair Value	3,997
Unrealized Losses	(3)
In Continuous Loss Position Greater Than Twelve Months [Member] \| Agency Bonds – Presented in Marketable Debt Securities [Member]
Security Owned Not Readily Marketable [Line Items]
Estimated Fair Value
Unrealized Losses

Stock-Based Compensation (Details) - Schedule of Stock Option Activities - USD ($)
$ / shares in Units, $ in Thousands

12 Months Ended

Dec. 31, 2023

Dec. 31, 2022

Stock-Based Compensation [Line Items]

Weighted Average Exercise Price, beginning

$ 14.23

Weighted Average Remaining Contractual Term (years), beginning

8 years 10 days

8 years 1 month 28 days

Aggregate Intrinsic Value, beginning

^[1]

Weighted Average Exercise Price, Balance at ending

$ 9.5

Weighted Average Remaining Contractual Term (years), Balance at ending

8 years 10 days

8 years 1 month 28 days

Aggregate Intrinsic Value, Balance at ending

^[1]

$ 20

Weighted Average Exercise Price, Vested or expected to vest

$ 9.5

Weighted Average Remaining Contractual Term (years), Vested or expected to vest

8 years 10 days

Aggregate Intrinsic Value, Vested or expected to vest

^[1]

$ 20

Weighted Average Exercise Price, Exercisable

$ 15.48

Weighted Average Remaining Contractual Term (years), Exercisable

7 years 29 days

Aggregate Intrinsic Value, Exercisable

^[1]

Weighted Average Exercise Price, Granted

$ 2.99

Aggregate Intrinsic Value, Granted

^[1]

Weighted Average Exercise Price, Exercised

Weighted Average Exercise Price, Forfeited

$ 6.83

Aggregate Intrinsic Value, Forfeited

^[1]

Weighted Average Exercise Price, Expired

$ 15.94

Aggregate Intrinsic Value, Expired

^[1]

Equity Option [Member]

Stock-Based Compensation [Line Items]

Number of Options, beginning

1,828,329

Number of Options, Balance at ending

2,900,205

Number of Options, Vested or expected to vest

2,900,205

Number of Options, Exercisable

1,242,111

Number of Options, Granted

1,310,900

Number of Options, Exercised

Number of Options, Forfeited

(157,523)

Number of Options, Expired

(81,501)

[1]	Aggregate intrinsic value represents the difference between the exercise price of the option and the closing market price of our common stock on December 31, 2023. The intrinsic value of options exercised during the years ended December 31, 2023 and 2022 was $0 and no options were exercised.

Accrued Expenses

12 Months Ended

Dec. 31, 2023

Accrued Expenses [Abstract]

Accrued Expenses

8. Accrued Expenses

Accrued expenses consist of the following as of:

	December 31,
	2023		2022
Employee costs	$	2,112	$	2,543
Research and development		440		512
Other expenses		180		182
Total	$	2,732	$	3,237

Commitments and Contingencies (Details) $ in Thousands		12 Months Ended
Commitments and Contingencies (Details) $ in Thousands	Dec. 22, 2017 USD ($)	Dec. 31, 2023 USD ($)	Dec. 31, 2022 USD ($)
Commitments and Contingencies [Line Items]
Royalty expense lower range		$ 25
Royalty expense upper range		75
Maximum additional milestone payments		775
Research and development expense		$ 24,989	$ 16,808
License Agreement Terms [Member]
Commitments and Contingencies [Line Items]
Number of research labs	50
Number of clinical research studies	2,500
Royalty terms	1.00%
Royalty terms sales	$ 100,000
Royalty terms additonal royalty	1.50%
Royalty net proceeds	12.50%
Royalty terms initial term	2 years
After agreement royalty net proceeds percentage	7.50%
New drug application milestones	$ 275
Terms of Iowa Agreement [Member]
Commitments and Contingencies [Line Items]
License agreement description		During the term of the services, the Company would generally pay the University of Iowa thirty thousand dollars ($30) per year to fund the project, plus additional amounts upon the realization of certain milestones. More specifically, upon forty-five (45) days of an approval of TARA-002 by the FDA, the Company would pay up to $1,750 to the University of Iowa for meeting these milestones. Furthermore, the Company would pay the University of Iowa royalties of up to 1.75% for net sales ranging from $0 - $25,000, 2.25% for net sales ranging from $25,000 to $50,000, and 2.50% for net sales in excess of $50,000. Pursuant to the Iowa Agreement, the University of Iowa would be entitled to additional payments for the Company achieving annual net sales of product according to the milestones. For annual net sales of product up to $25,000: $62; for annual net sales of product of up to $50,000: $62; and for annual net sales of product of up to $100,000: $125.
Iowa Agreement [Member]
Commitments and Contingencies [Line Items]
Research and development expense		$ 27	$ 2
Feinstein Agreement [Member]
Commitments and Contingencies [Line Items]
Research and development expense		$ 15	$ 17

Employee Benefit Plan (Details) - USD ($) $ in Thousands	12 Months Ended
Employee Benefit Plan (Details) - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Retirement Benefits [Abstract]
Employee contributions	100.00%
Employee compensation	4.00%
Other expenses	$ 237	$ 223

Income Taxes (Tables)

12 Months Ended

Dec. 31, 2023

Income Taxes [Abstract]

Schedule of Federal and State Income Tax Expense

Federal and State income tax expense is as follows:

	For the Years Ended December 31,
	2023			2022
Current
Federal	$	-		$	-
State		-			-
Total current		-			-
Deferred
Federal		(9,627	)		(7,954	)
State		(4,124	)		(1,068	)
Total deferred		(13,751	)		(9,022	)
Change in valuation allowance		13,751			9,022
Total income tax expense (benefit)	$	-		$	-

Schedule of Deferred Tax Assets and Liabilities

The tax effects of temporary differences that give rise to significant portions of the deferred tax assets are as follows:

	As of December 31,
	2023			2022
Deferred tax assets:
Net operating loss carry forwards	$	30,731		$	26,768
Capitalized research and development		9,611			3,418
Stock option expense		4,464			2,477
Research and development credits		4,824			3,710
Operating lease liability		1,485			1,481
RSU expense		2,723			2,199
Other		467			408
Total deferred tax assets		54,305			40,461
Valuation allowance		(52,734	)		(38,983	)
Deferred tax assets, net of valuation allowance		1,571			1,478
Deferred tax liabilities:
Operating right-of-use asset		(1,430	)		(1,456	)
Other		(141	)		(22	)
Total deferred tax liabilities		(1,571	)		(1,478	)
Deferred tax assets, net of valuation allowance and deferred tax liabilities	$	-		$	-

Schedule of Federal Income Tax to Income Before Provision for Income Taxes

A reconciliation of the provision for income taxes with the amounts computed by applying the statutory Federal income tax to income before provision for income taxes is as follows:

	For the Years Ended December 31,
	2023			2022
U.S. federal statutory rate		(21.0	)%		(21.0	)%
State taxes, net of federal benefit		(7.8	)%		(2.2	)%
State rate change		(4.0	)%		-	%
Research and development credits		(2.4	)%		(3.3	)%
True-up to prior years return		2.2	%		(0.7	)%
Stock-based compensation		(1.3	)%		0.1	%
Other		0.4	%		(0.3	)%
Goodwill impairment		-	%		10.4	%
Change in valuation allowance		33.9	%		17.0	%
Effective tax rate		-	%		-	%

Leases (Details) - Schedule of Weighted Average Remaining Lease Term and the Weighted Average Discount Rate for Operating Leases	Dec. 31, 2023	Dec. 31, 2022
Schedule of Lease Expense [Abstract]
Weighted-average discount rate	7.00%	7.00%
Weighted-average remaining lease term – operating lease (in months)	55 months	67 months

Net Loss Per Common Share

12 Months Ended

Dec. 31, 2023

Net Loss Per Common Share [Abstract]

Net Loss Per Common Share

15. Net Loss per Common Share

The following table sets forth the computation of the net loss per share attributable to common stockholders, basic and diluted:

	December 31,
	2023			2022
Numerator:
Net loss attributable to common stockholders	$	(40,420	)	$	(65,952	)
Denominator:
Weighted-average common shares outstanding – basic and diluted		11,331,338			11,259,615
Net loss per share attributable to common stockholders, basic and diluted	$	(3.57	)	$	(5.86	)

Since the Company was in a net loss position for all periods presented, net loss per share attributable to common stockholders was the same on a basic and diluted basis, as the inclusion of all potential common equivalent shares outstanding would have been anti-dilutive. The Company excluded the following potential common shares, presented based on amounts outstanding at each period end, from the computation of diluted net loss per share attributable to common stockholders for the periods indicated because including them would have had an anti-dilutive effect:

	December 31,
	2023		2022
Stock options issued and outstanding		2,900,205		1,828,329
Restricted stock units issued and outstanding		526,179		486,338
Conversion of Series 1 Convertible Preferred Stock		7,993,217		8,029,039
Total potentially dilutive shares		11,419,601		10,343,706

Consolidated Balance Sheets - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Current assets:
Cash and cash equivalents	$ 39,586	$ 24,127
Marketable debt securities	25,994	60,243
Prepaid expenses and other current assets	3,125	1,776
Total current assets	68,705	86,146
Restricted cash, non-current	745	745
Marketable debt securities, non-current		17,886
Property and equipment, net	1,296	1,592
Operating lease right-of-use asset	5,264	6,277
Other assets	2,944	644
Total assets	78,954	113,290
Current liabilities:
Accounts payable	2,434	1,586
Accrued expenses	2,732	3,237
Operating lease liability	983	917
Total current liabilities	6,149	5,740
Operating lease liability, non-current	4,484	5,467
Total liabilities	10,633	11,207
Commitments and contingencies (Note 10)
Stockholders’ Equity:
Preferred stock, $0.001 par value, authorized 10,000,000 shares: Series 1 convertible preferred stock, 8,028 shares authorized at December 31, 2023 and 2022, 7,991 and 8,027 shares issued and outstanding as of December 31, 2023 and 2022, respectively.
Common stock, $0.001 par value, authorized 100,000,000 shares: Common stock, 11,364,903 and 11,267,389 shares issued and outstanding as of December 31, 2023 and 2022, respectively.	11	11
Additional paid in capital	268,725	262,724
Accumulated deficit	(200,384)	(159,964)
Accumulated other comprehensive income (loss)	(31)	(688)
Total stockholders’ equity	68,321	102,083
Total liabilities and stockholders’ equity	$ 78,954	$ 113,290

Cover - USD ($) $ in Millions	12 Months Ended
Cover - USD ($) $ in Millions	Dec. 31, 2023	Mar. 08, 2024	Jun. 30, 2023
Document Information [Line Items]
Document Type	10-K
Document Annual Report	true
Document Transition Report	false
Document Financial Statement Error Correction [Flag]	false
Entity Interactive Data Current	Yes
ICFR Auditor Attestation Flag	false
Amendment Flag	false
Document Period End Date	Dec. 31, 2023
Document Fiscal Year Focus	2023
Document Fiscal Period Focus	FY
Documents Incorporated by Reference [Text Block]	Portions of the registrant’s definitive Proxy Statement to be filed with the Securities and Exchange Commission by April 29, 2024 are incorporated by reference into Part III of this report.
Entity Information [Line Items]
Entity Registrant Name	Protara Therapeutics, Inc.
Entity Central Index Key	0001359931
Entity File Number	001-36694
Entity Tax Identification Number	20-4580525
Entity Incorporation, State or Country Code	DE
Current Fiscal Year End Date	--12-31
Entity Well-known Seasoned Issuer	No
Entity Voluntary Filers	No
Entity Current Reporting Status	Yes
Entity Shell Company	false
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	false
Entity Public Float			$ 18.0
Entity Contact Personnel [Line Items]
Entity Address, Address Line One	345 Park Avenue South
Entity Address, Address Line Two	3rd Floor
Entity Address, City or Town	New York
Entity Address, State or Province	NY
Entity Address, Postal Zip Code	10010
Entity Phone Fax Numbers [Line Items]
City Area Code	(646)
Local Phone Number	844-0337
Entity Listings [Line Items]
Title of 12(b) Security	common stock, par value $0.001 per share
Trading Symbol	TARA
Security Exchange Name	NASDAQ
Entity Common Stock, Shares Outstanding		11,433,837

Summary of Significant Accounting Policies (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Summary of Significant Accounting Policies [Line Items]
Market capitalizations percentage change		60.00%
Market capitalization of microcap companies (in Dollars)		$ 250,000
Impairment of goodwill (in Dollars)		$ 29,517
Stock option period	4 years
Percentage of largest amount of benefit	50.00%
Restricted Stock Units (RSUs) [Member] \| Minimum [Member]
Summary of Significant Accounting Policies [Line Items]
Vesting period	1 year
Restricted Stock Units (RSUs) [Member] \| Maximum [Member]
Summary of Significant Accounting Policies [Line Items]
Vesting period	4 years

Prepaid Expenses and Other Current Assets

12 Months Ended

Dec. 31, 2023

Prepaid Expenses and Other Current Assets [Abstract]

Prepaid Expenses and Other Current Assets

5. Prepaid Expenses and Other Current Assets

Prepaid expenses and other current assets consist of the following as of:

	December 31,
	2023		2022
Prepaid research and development	$	1,957	$	569
Prepaid insurance		659		288
Accrued interest on marketable debt securities		242		486
Other prepaid expenses		163		184
Prepaid software		67		122
Other current assets		37		127
Total	$	3,125	$	1,776

Leases (Details) $ in Thousands	12 Months Ended
Leases (Details) $ in Thousands	Dec. 31, 2023 USD ($) ft²	Dec. 31, 2022 USD ($)
Leases [Abstract]
Lease of office space (in Square Feet) \| ft²	10,300
Annual rent	$ 1,117
Restricted cash	745	$ 745
Cash paid for operating lease liabilities	$ 1,234	$ 1,327

Fair Value of Financial Instruments (Tables)

12 Months Ended

Dec. 31, 2023

Fair Value of Financial Instruments [Abstract]

Schedule of Financial Assets and Liabilities that are Measured and Carried at Fair Value

	December 31, 2023
	Level 1		Level 2		Level 3		Total
Cash equivalents:
Money market funds^(a)	$	39,031	$	-	$	-	$	39,031
Restricted cash, non-current:
Money market funds^(b)		745		-		-		745
Marketable debt securities:
Corporate bonds^(c)		-		23,495		-		23,495
Agency bonds^(c)		-		2,499		-		2,499
Total	$	39,776	$	25,994	$	-	$	65,770

	December 31, 2022
	Level 1		Level 2		Level 3		Total
Cash equivalents:
Money market funds^(a)	$	13,284	$	-	$	-	$	13,284
Corporate bonds^(a)		-		2,523		-		2,523
Restricted cash, non-current:
Money market funds^(b)		745		-		-		745
Marketable debt securities:
Corporate bonds^(c)		-		78,129		-		78,129
Total	$	14,029	$	80,652	$	-	$	94,681

(a)	Money market funds and bonds with original maturities of 90 days or less are included within Cash and cash equivalents in the consolidated balance sheets.

(b)	Restricted Money market funds are included within Restricted Cash, non-current in the consolidated balance sheets.

(c)	Bonds with original maturities greater than 90 days are included within Marketable debt securities in the consolidated balance sheets and classified as current or noncurrent based upon whether the maturity of the financial asset is less than or greater than 12 months.

Consolidated Statements of Changes in Stockholders’ Equity - USD ($) $ in Thousands	Series 1 Convertible Preferred Stock	Common Stock	Additional Paid-in Capital	Accumulated Deficit	Accumulated Other Comprehensive Income (Loss)	Total
Balance at Dec. 31, 2021		$ 11	$ 256,126	$ (94,012)	$ (211)	$ 161,914
Balance (in Shares) at Dec. 31, 2021	8,027	11,235,731
Settlement of restricted stock units			(90)			(90)
Settlement of restricted stock units (in Shares)		31,658
Stock-based compensation - restricted stock units			1,273			1,273
Stock-based compensation - stock options			5,415			5,415
Net unrealized (loss) gain on marketable debt securities					(477)	(477)
Net loss				(65,952)		(65,952)
Balance at Dec. 31, 2022		$ 11	262,724	(159,964)	(688)	102,083
Balance (in Shares) at Dec. 31, 2022	8,027	11,267,389
Settlement of restricted stock units			(91)			(91)
Settlement of restricted stock units (in Shares)		61,691
Stock-based compensation - restricted stock units			1,208			1,208
Stock-based compensation - stock options			4,884			4,884
Conversion of series 1 convertible preferred stock to common stock
Conversion of series 1 convertible preferred stock to common stock (in Shares)	(36)	35,823
Net unrealized (loss) gain on marketable debt securities					657	657
Net loss				(40,420)		(40,420)
Balance at Dec. 31, 2023		$ 11	$ 268,725	$ (200,384)	$ (31)	$ 68,321
Balance (in Shares) at Dec. 31, 2023	7,991	11,364,903

Marketable Debt Securities

12 Months Ended

Dec. 31, 2023

Marketable Debt Securities [Abstract]

Marketable Debt Securities

4. Marketable Debt Securities

Marketable debt securities, all of which were classified as available-for-sale, consist of the following as of:

	December 31, 2023
	Amortized Cost		Unrealized Gains		Unrealized Losses			Estimated Fair Value
Corporate bonds – presented in marketable debt securities	$	23,525	$	-	$	(30	)	$	23,495
Agency bonds – presented in marketable debt securities		2,500		-		(1	)		2,499
Total	$	26,025	$	-	$	(31	)	$	25,994

	December 31, 2022
	Amortized Cost		Unrealized Gains		Unrealized Losses			Estimated Fair Value
Corporate bonds - presented in marketable debt securities	$	60,790	$	-	$	(547	)	$	60,243
Corporate bonds - presented in marketable debt securities, non-current		18,027		-		(141	)		17,886
Total	$	78,817	$	-	$	(688	)	$	78,129

The amount of realized gains and losses reclassified into earnings for the years ended December 31, 2023 and December 31, 2022 was $0 and $17, respectively. These gains were included in investment income within the consolidated statements of operations and comprehensive loss. There were no sales of securities in the periods presented.

The Company has recorded the securities at fair value in its consolidated balance sheets and unrealized gains and losses are reported as a component of accumulated other comprehensive income (loss). The amount of realized gains and losses reclassified into earnings are based on the specific identification of the securities sold or securities that reached maturity date. The amount of realized gains and losses reclassified into earnings have not been material to the Company’s consolidated statements of operations and comprehensive income.

At the time of purchase, the Company determines the appropriate classification of investments based upon its intent with regard to such investments. The Company classifies investments in marketable debt securities with remaining maturities when purchased of greater than three months as available-for-sale. Investments with a remaining maturity date greater than one year are classified as non-current. The contractual maturities of all securities held at December 31, 2023 was 4 months or less. There were no sales of securities in the periods presented.

Credit Losses

Securities with an amortized cost basis in excess of estimated fair value are assessed to determine what amount of the excess, if any, is caused by expected credit losses. For the year ended December 31, 2023, it was determined that none of the unrealized loss is related to expected credit losses as the Company has the ability and intent to hold all marketable securities that have been in a continuous loss position until maturity or recovery. Further, the entire portfolio is held with investment grade high credit quality institutions. The Company intends to continue investing only in such securities. Expected credit losses, if they existed, would be recognized in other income (expense), net within the Company’s consolidated statement of operations and comprehensive income. The remaining unrealized losses, not related to credit losses, net of taxes, are included in accumulated other comprehensive loss in stockholders’ equity within the Company’s consolidated balance sheets.

Marketable debt securities in a loss position consist of the following as of:

	December 31, 2023
	In Continuous Loss Position Less Than 12 Months					In Continuous Loss Position Greater Than 12 Months					Total
	Estimated Fair Value		Unrealized Losses			Estimated Fair Value		Unrealized Losses			Estimated Fair Value		Unrealized Losses
December 31, 2023
Corporate bonds – presented in marketable debt securities	$	19,498	$	(27	)	$	3,997	$	(3	)	$	23,495	$	(30	)
Agency bonds – presented in marketable debt securities		2,499		(1	)		-		-			2,499		(1	)
Total	$	21,997	$	(28	)	$	3,997	$	(3	)	$	25,994	$	(31	)

Interest and Investment Income

Interest and investment income consists of the following for the year ended:

	December 31,
	2023		2022
Interest income	$	2,727	$	2,230
Accretion/(Amortization) of discount/premium, net		454		(1,137	)
Dividend income		12		-
Realized gain/loss		-		17
Total interest and investment income	$	3,193	$	1,110

Summary of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2023

Summary of Significant Accounting Policies [Abstract]

Schedule of Cash, Cash Equivalents, and Restricted Cash

The following table provides a reconciliation of cash, cash equivalents, and restricted cash in the consolidated balance sheets to the total amount shown in the consolidated statements of cash flows:

	December 31,
	2023		2022
Cash and cash equivalents	$	39,586	$	24,127
Restricted cash, non-current		745		745
Total cash, cash equivalents and restricted cash shown in the consolidated statements of cash flows	$	40,331	$	24,872

Schedule of Estimated Useful Lives for Significant Property and Equipment

The estimated useful lives for significant property and equipment categories are as follows:

Asset Classification		Estimated Useful Life
Computer equipment		3-5 years
Furniture, fixtures and other		5 years
Laboratory equipment		7 years
Leasehold improvements		Shorter of the useful life of asset or the lease term

Schedule of Goodwill and Accumulated Impairment Losses

The following table provides a roll forward of the Company’s goodwill and accumulated impairment losses:

	Goodwill
Goodwill, gross amount as of January 1, 2022	$	29,517
Loss on impairment		(29,517	)
Goodwill as of December 31, 2022	$	-

Net Loss Per Common Share (Details) - Schedule of Net Loss Per Share Attributable to Common Stockholders, Basic and Diluted - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Numerator:
Net loss attributable to common stockholders	$ (40,420)	$ (65,952)
Denominator:
Weighted-average common shares outstanding – basic	11,331,338	11,259,615
Net loss per share attributable to common stockholders, basic	$ (3.57)	$ (5.86)

- Definition

The amount of net income (loss) for the period per each share of common stock or unit outstanding during the reporting period.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 250
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 3
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147483443/250-10-50-3

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 260
-SubTopic 10
-Name Accounting Standards Codification
-Section 55
-Paragraph 15
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482635/260-10-55-15

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Topic 815
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-Name Accounting Standards Codification
-Section 65
-Paragraph 1
-Subparagraph (e)(4)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480175/815-40-65-1

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Topic 815
-SubTopic 40
-Name Accounting Standards Codification
-Section 65
-Paragraph 1
-Subparagraph (f)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480175/815-40-65-1

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Topic 250
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 11
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147483443/250-10-50-11

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Topic 250
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 11
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147483443/250-10-50-11

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Topic 250
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 7
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147483443/250-10-50-7

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Topic 260
-SubTopic 10
-Name Accounting Standards Codification
-Section 45
-Paragraph 2
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482689/260-10-45-2

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Topic 260
-SubTopic 10
-Name Accounting Standards Codification
-Section 45
-Paragraph 60B
-Subparagraph (d)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482689/260-10-45-60B

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Topic 250
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 4
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147483443/250-10-50-4

Reference 11: http://www.xbrl.org/2003/role/disclosureRef
-Topic 260
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 1
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482662/260-10-50-1

Reference 12: http://www.xbrl.org/2003/role/disclosureRef
-Topic 260
-SubTopic 10
-Name Accounting Standards Codification
-Section 45
-Paragraph 10
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- Definition

Amount, after deduction of tax, noncontrolling interests, dividends on preferred stock and participating securities; of income (loss) available to common shareholders.

+ References

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+ Details

Stock-Based Compensation (Details) - Schedule of Stock-Based Compensation Costs - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Stock-Based Compensation [Line Items]
Total	$ 6,092	$ 6,688
RSUs [Member]
Stock-Based Compensation [Line Items]
RSUs	1,208	1,272
Stock options [Member]
Stock-Based Compensation [Line Items]
Stock options	$ 4,884	$ 5,416

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

+ Details

Marketable Debt Securities (Details) - Schedule of Interest and Investment Income - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Marketable Debt Securities [Abstract]
Interest income	$ 2,727	$ 2,230
Accretion/(Amortization) of discount/premium, net	454	(1,137)
Dividend income	12
Realized gain/loss	0	17
Total interest and investment income	$ 3,193	$ 1,110

- Definition

Amount of operating dividend income on securities.

+ References + Details

Marketable Debt Securities (Tables)

12 Months Ended

Dec. 31, 2023

Marketable Debt Securities [Abstract]

Schedule of Marketable Debt Securities in a Loss Position

Marketable debt securities, all of which were classified as available-for-sale, consist of the following as of:

	December 31, 2023
	Amortized Cost		Unrealized Gains		Unrealized Losses			Estimated Fair Value
Corporate bonds – presented in marketable debt securities	$	23,525	$	-	$	(30	)	$	23,495
Agency bonds – presented in marketable debt securities		2,500		-		(1	)		2,499
Total	$	26,025	$	-	$	(31	)	$	25,994

	December 31, 2022
	Amortized Cost		Unrealized Gains		Unrealized Losses			Estimated Fair Value
Corporate bonds - presented in marketable debt securities	$	60,790	$	-	$	(547	)	$	60,243
Corporate bonds - presented in marketable debt securities, non-current		18,027		-		(141	)		17,886
Total	$	78,817	$	-	$	(688	)	$	78,129

Schedule of Marketable Debt Securities in a Loss Position

Marketable debt securities in a loss position consist of the following as of:

	December 31, 2023
	In Continuous Loss Position Less Than 12 Months					In Continuous Loss Position Greater Than 12 Months					Total
	Estimated Fair Value		Unrealized Losses			Estimated Fair Value		Unrealized Losses			Estimated Fair Value		Unrealized Losses
December 31, 2023
Corporate bonds – presented in marketable debt securities	$	19,498	$	(27	)	$	3,997	$	(3	)	$	23,495	$	(30	)
Agency bonds – presented in marketable debt securities		2,499		(1	)		-		-			2,499		(1	)
Total	$	21,997	$	(28	)	$	3,997	$	(3	)	$	25,994	$	(31	)

Schedule of Interest and Investment Income

Interest and investment income consists of the following for the year ended:

	December 31,
	2023		2022
Interest income	$	2,727	$	2,230
Accretion/(Amortization) of discount/premium, net		454		(1,137	)
Dividend income		12		-
Realized gain/loss		-		17
Total interest and investment income	$	3,193	$	1,110

Stock-Based Compensation

12 Months Ended

Dec. 31, 2023

Stock-Based Compensation [Abstract]

Stock-Based Compensation

12. Stock-Based Compensation

2020 Inducement Plan

On March 26, 2020, the Compensation Committee of the Board of Directors, or the Compensation Committee, approved the ArTara Therapeutics, Inc. Inducement Plan, or the 2020 Inducement Plan, in order to award nonstatutory stock options, restricted stock awards, restricted stock unit awards and other stock-based awards to persons not previously an employee or director of the Company, or following a bona fide period of non-employment, as an inducement material to such persons entering into employment with the Company.

The 2020 Inducement Plan provides for a total of 600,000 shares for the issuance of the Company’s common stock. The Compensation Committee also adopted a form of stock option grant notice and stock option agreement and forms of restricted stock unit grant notice and restricted stock unit agreement for use with the Inducement Plan.

As of December 31, 2023, there were 409,000 shares of common stock subject to outstanding awards and 191,000 shares of common stock available for future issuance under the 2020 Inducement Plan.

2017 Equity Incentive Plan

On August 10, 2017, Private ArTara, (a predecessor of the Company), its Board of Directors and its stockholders approved the ArTara Therapeutics, Inc. 2017 Equity Incentive Plan to enable Private ArTara and its affiliates to recruit and retain highly qualified personnel and to incentivize personnel for productivity and growth.

The 2017 Equity Incentive Plan provided for the grant of a total of 2,000,000 shares for the issuance of stock options, stock appreciation rights, restricted stock and restricted stock units to among others, members of the Board of Directors, employees, consultants and service providers to the Company and its affiliates. As of January 9, 2020, in connection with the Merger, no additional awards will be made under the 2017 Equity Incentive Plan.

2014 Equity Incentive Plan

On October 3, 2014, the stockholders approved the 2014 Equity Incentive Plan. On June 20, 2017, the Company’s Board of Directors amended the 2014 Equity Incentive Plan, or the Amended and Restated 2014 Plan. On July 31, 2017, the stockholders approved this amendment. On January 1, 2020, Protara Therapeutics, Inc. amended its Amended and Restated 2014 Equity Incentive Plan to increase the number of shares of stock available for issuance under the 2014 Equity Incentive Plan to 1,048,300 shares and made conforming changes and updates pursuant to Section 162(m) of the Code.

The Amended and Restated 2014 Plan provides for the grant of incentive and non-statutory stock options, stock appreciation rights, restricted stock and stock unit awards, performance units, stock grants and qualified performance-based awards. The Amended and Restated 2014 Plan provides that the number of shares reserved and available for issuance will automatically increase each January 1, by four percent of the Company’s common stock on the immediately preceding December 31, adjusted for the number of shares of the Company’s common stock issuable upon conversion of any security that the Company may issue that is convertible into or exchangeable for the Company’s common stock, or such lesser number of shares as determined by the Company’s Board of Directors.

Terms of the stock awards, including vesting requirements, are determined by the Board of Directors, subject to the provisions of the plans. Certain awards provide for accelerated vesting if there is a change in control as defined in the plans.

On January 1, 2023, pursuant to the annual evergreen feature of the Amended and Restated 2014 Plan, as amended, the number of shares authorized under the Amended and Restated 2014 Plan, as amended, was increased by 861,933 shares to 3,563,303 shares. As of December 31, 2023, there were 2,883,056 shares of common stock subject to outstanding awards and 547,382 shares of common stock available for future issuance under the Amended 2014 Plan.

On January 1, 2024, pursuant to the annual evergreen feature of the Amended and Restated 2014 Plan, as amended, the number of shares authorized under the Amended and Restated 2014 Plan, as amended, was increased by 911,380 shares to 4,474,683 shares.

2014 Employee Stock Purchase Plan

On October 3, 2014, the stockholders approved the 2014 Employee Stock Purchase Plan, or the 2014 ESPP. The 2014 ESPP initially authorized the issuance of up to 3,513 shares of the Company’s common stock. The number of shares increases each January 1, commencing on January 1, 2015 and ending on (and including) January 1, 2024, by an amount equal to the lesser of one percent of the outstanding shares as of the end of the immediately preceding fiscal year, 7,025 shares or any lower amount determined by the Company’s Board of Directors prior to each such January 1st.

On January 1, 2023, pursuant to the increase per the 2014 ESPP, the number of shares authorized under the 2014 ESPP was increased by 7,025 shares to 39,087 shares. As of December 31, 2023, the authorized number of shares under the 2014 ESPP is 39,087 and the number of shares available for issuance is 39,087. During the years ended December 31, 2023 and 2022, no shares were issued under the 2014 ESPP.

On January 1, 2024, pursuant to the increase per the 2014 ESPP, the number of shares authorized under the 2014 ESPP was increased by 7,025 shares to 46,112 shares.

Restricted Stock Units

The following table summarizes restricted stock unit activity:

	Restricted Stock Units			Weighted Average Grant Date Fair Value
Non-vested at December 31, 2022		196,838		$	12.49
Granted		165,100			3.02
Forfeited		(30,731	)		4.35
Vested		(94,528	)		12.16
Non-vested at December 31, 2023		236,679		$	7.07

The fair value of RSUs is amortized on a straight-line basis over the requisite service period of the respective awards. As of December 31, 2023, the unamortized value of RSUs was $569. As of December 31, 2023, the weighted average remaining amortization period was 1.55 years. As of December 31, 2023 and 2022, 289,500 and 289,500 RSUs, respectively, have vested that have not yet been settled into shares of the Company’s common stock.

During the year ended December 31, 2023, the Company issued 61,691 shares of the Company’s common stock from the net settlement of 94,528 RSUs. The Company paid $91 in connection with the net share settlement of these RSUs.

Stock Options

The Company determined the fair value of stock options granted utilizing the Black-Scholes valuation model and based upon the assumptions as provided below:

	For the Years Ended December 31,
	2023			2022
Exercise price		$1.20 - $3.91			$2.77 - $6.90
Dividend yield		0.00	%		0.00	%
Expected volatility		90.00% - 98.00	%		92.00% - 99.00	%
Risk-free interest rate		3.46% - 4.73	%		1.46% - 4.23	%
Expected life (in years)		5.27 - 6.08			5.27 - 6.08

The following table summarizes stock option activities for the year ended December 31, 2023:

	Number of Options			Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (years)		Aggregate Intrinsic Value (1)
Outstanding at December 31, 2022		1,828,329		$	14.23		8.16	$	-
Granted		1,310,900			2.99
Exercised		-			-
Forfeited		(157,523	)		6.83
Expired		(81,501	)		15.94
Outstanding at December 31, 2023		2,900,205		$	9.50		8.03	$	20

Vested or expected to vest at December 31, 2023		2,900,205		$	9.50		8.03	$	20
Exercisable as of December, 31 2023		1,242,111		$	15.48		7.08	$	-

(1)

The weighted average grant date fair value per share of the options granted during the years ended December 31, 2023 and 2022 was $2.36 and $4.80, respectively. As of December 31, 2023, there was approximately $5,699 of unrecognized share-based compensation for unvested stock option grants which is expected to be recognized over a weighted average period of 2.59 years. The total unrecognized share-based compensation cost will be adjusted for actual forfeitures as they occur.

Summary of Stock-Based Compensation Expense

The following tables summarize total stock-based compensation costs recognized:

	For the Years Ended December 31,
	2023		2022
RSUs	$	1,208	$	1,272
Stock options		4,884		5,416
Total	$	6,092	$	6,688

Stock-based compensation expense was reflected within the consolidated statements of operations and comprehensive loss:

	For the Years Ended December 31,
	2023		2022
Research and development	$	1,653	$	1,511
General and administrative		4,439		5,177
Total	$	6,092	$	6,688

Prepaid Expenses and Other Current Assets (Details) - Schedule of Prepaid Expenses and Other Current Assets - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Prepaid Expenses and Other Current Assets [Abstract]
Prepaid research and development	$ 1,957	$ 569
Prepaid insurance	659	288
Accrued interest on marketable debt securities	242	486
Other prepaid expenses	163	184
Prepaid software	67	122
Other current assets	37	127
Total	$ 3,125	$ 1,776

Property and Equipment, Net (Details) - Schedule of Property and Equipment, Net - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Property, Plant and Equipment [Line Items]
Total property and equipment, gross	$ 2,120	$ 2,075
Less: Accumulated depreciation	(824)	(483)
Total property and equipment, net	1,296	1,592
Computer equipment [Member]
Property, Plant and Equipment [Line Items]
Total property and equipment, gross	247	205
Furniture, fixtures and other [Member]
Property, Plant and Equipment [Line Items]
Total property and equipment, gross	352	352
Laboratory equipment [Member]
Property, Plant and Equipment [Line Items]
Total property and equipment, gross	913	866
Leasehold improvements [Member]
Property, Plant and Equipment [Line Items]
Total property and equipment, gross	553	553
Property and equipment not yet placed into service [Member]
Property, Plant and Equipment [Line Items]
Total property and equipment, gross	$ 55	$ 99

Prepaid Expenses and Other Current Assets (Tables)

12 Months Ended

Dec. 31, 2023

Prepaid Expenses and Other Current Assets [Abstract]

Schedule of Prepaid Expenses and Other Current Assets

Prepaid expenses and other current assets consist of the following as of:

	December 31,
	2023		2022
Prepaid research and development	$	1,957	$	569
Prepaid insurance		659		288
Accrued interest on marketable debt securities		242		486
Other prepaid expenses		163		184
Prepaid software		67		122
Other current assets		37		127
Total	$	3,125	$	1,776

Summary of Significant Accounting Policies (Details) - Schedule of Goodwill and Accumulated Impairment Losses - Goodwill [Member] $ in Thousands	12 Months Ended
	Dec. 31, 2022 USD ($)
Schedule of Goodwill and Accumulated Impairment Losses [Line Items]
Goodwill, gross amount begining	$ 29,517
Loss on impairment	(29,517)
Goodwill ending

- Definition

Amount after accumulated impairment loss of an asset representing future economic benefits arising from other assets acquired in a business combination that are not individually identified and separately recognized.

+ References + Details

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

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+ Details

Property and Equipment, Net (Tables)

12 Months Ended

Dec. 31, 2023

Property and Equipment, Net [Abstract]

Schedule of Property and Equipment, Net

Property and equipment, net consists of the following as of:

	December 31,
	2023			2022
Computer equipment	$	247		$	205
Furniture, fixtures and other		352			352
Laboratory equipment		913			866
Leasehold improvements		553			553
Property and equipment not yet placed into service		55			99
Total property and equipment		2,120			2,075
Less: Accumulated depreciation		(824	)		(483	)
Total property and equipment, net	$	1,296		$	1,592

Property and Equipment, Net (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Property, Plant and Equipment [Line Items]
Depreciation expense	$ 341	$ 248
Property, Plant and Equipment [Member]
Property, Plant and Equipment [Line Items]
Depreciation expense	$ 341	$ 247
US [Member]
Property, Plant and Equipment [Line Items]
Percentage of property and equipment	100.00%	100.00%
Research and Development Expense [Member]
Property, Plant and Equipment [Line Items]
Depreciation expense	$ 204	$ 137
General and Administrative Expense [Member]
Property, Plant and Equipment [Line Items]
Depreciation expense	$ 137	$ 110

Summary of Significant Accounting Policies (Details) - Schedule of Estimated Useful Lives for Significant Property and Equipment	12 Months Ended
	Dec. 31, 2023
Computer equipment [Member] \| Minimum [Member]
Property, Plant and Equipment [Line Items]
Estimated Useful Life	3 years
Computer equipment [Member] \| Maximum [Member]
Property, Plant and Equipment [Line Items]
Estimated Useful Life	5 years
Furniture, fixtures and other [Member]
Property, Plant and Equipment [Line Items]
Estimated Useful Life	5 years
Laboratory equipment [Member]
Property, Plant and Equipment [Line Items]
Estimated Useful Life	7 years
Leasehold improvements [Member]
Property, Plant and Equipment [Line Items]
Estimated Useful Life	Shorter of the useful life of asset or the lease term

Income Taxes (Details) - USD ($)	12 Months Ended
Income Taxes (Details) - USD ($)	Dec. 31, 2023	Dec. 31, 2022
Income Taxes [Line Items]
Effective tax rate	0.00%	0.00%
Federal rate	21.00%	21.00%
State taxes net of federal benefit	7.80%	2.20%
Apportionment changes percentage	4.00%
Valuation allowance	33.90%	17.00%
Research and development credits		3.30%
Prior year’s tax return		0.70%
Goodwill impairment percent		10.40%
Carried forward tax year	20 years
Valuation allowance (in Dollars)	$ 52,700,000	$ 39,000,000
Federal NOL [Member]
Income Taxes [Line Items]
Carried forward tax (in Dollars)	128,196
Federal NOL [Member] \| U.S. Federal and State Income Tax [Member]
Income Taxes [Line Items]
Carried forward tax (in Dollars)	600,000
U.S. federal [Member]
Income Taxes [Line Items]
Net operating losses (in Dollars)	$ 187,492	$ 114,800,000