SEC Form 4

FORM 4		UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940	OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response: 0.5
X	Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

1. Name and Address of Reporting Person* Flynn James E (Last) (First) (Middle) 780 THIRD AVENUE, 37TH FLOOR (Street) NEW YORK NY 10017 (City) (State) (Zip)	2. Issuer Name and Ticker or Trading Symbol PROTEON THERAPEUTICS INC [ PRTO ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director X 10% Owner Officer (give title below) X Other (specify below) Possible Member of 10% Group
	3. Date of Earliest Transaction (Month/Day/Year) 10/27/2014
	4. If Amendment, Date of Original Filed (Month/Day/Year)	6. Individual or Joint/Group Filing (Check Applicable Line) Form filed by One Reporting Person X Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	10/27/2014		C		406,896	A	(1)	406,896	I(3)	Through Deerfield Private Design Fund III, L.P.(4)(5)
Common Stock	10/27/2014		C		87,013	A	(1)	87,013	I(3)	Through Deerfield Special Situations Fund, L.P.(4)(5)
Common Stock	10/27/2014		C		69,485	A	(1)	69,485	I(3)	Through Deerfield Special Situations International Master Fund, L.P.(4)(5)
Common Stock	10/27/2014		P		469,495	A	$10	876,391	I(3)	Through Deerfield Private Design Fund III, L.P.(4)(5)
Common Stock	10/27/2014		P		98,556	A	$10	185,569	I(3)	Through Deerfield Special Situations Fund, L.P.(4)(5)
Common Stock	10/27/2014		P		81,949	A	$10	151,434	I(3)	Through Deerfield Special Situations International Master Fund, L.P.(4)(5)
Common Stock	10/27/2014		P		6,976	A	$10	192,545	I(3)	Through Deerfield Special Situations Fund, L.P.(4)(5)
Common Stock	10/27/2014		P		5,801	A	$10	157,235	I(3)	Through Deerfield Special Situations International Master Fund, L.P.(4)(5)
Common Stock	10/27/2014		P		15,417	A	$10	207,962	I(3)	Through Deerfield Special Situations Fund, L.P.(4)(5)
Common Stock	10/27/2014		P		12,819	A	$10	170,054	I(3)	Through Deerfield Special Situations International Master Fund, L.P.(4)(5)
Common Stock	10/27/2014		P		328	A	$10	208,290	I(3)	Through Deerfield Special Situations Fund, L.P.(4)(5)
Common Stock	10/27/2014		P		272	A	$10	170,326	I(3)	Through Deerfield Special Situations International Master Fund, L.P.(4)(5)
Common Stock	10/27/2014		P		55	A	$10	208,345	I(3)	Through Deerfield Special Situations Fund, L.P.(4)(5)
Common Stock	10/27/2014		P		45	A	$10	170,371	I(3)	Through Deerfield Special Situations International Master Fund, L.P.(4)(5)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Series D Preferred Stock	(1)	10/27/2014		C			6,134,501	(1)	(1)	Common Stock	406,896	(1)	0	I(3)	Through Deerfield Private Design Fund III, L.P.(4)(5)
Series D Preferred Stock	(1)	10/27/2014		C			1,311,840	(1)	(1)	Common Stock	87,013	(1)	0	I(3)	Through Deerfield Special Situations Fund, L.P.(4)(5)
Series D Preferred Stock	(1)	10/27/2014		C			1,047,584	(1)	(1)	Common Stock	69,485	(1)	0	I(3)	Through Deerfield Special Situations International Master Fund, L.P.(4)(5)
Series D Purchase Right	(2)	10/27/2014		J			4,907,601	(2)	(2)	Common Stock	309,238(2)	(2)	0	I(3)	Through Deerfield Private Design Fund III, L.P.(4)(5)
Series D Purchase Right	(2)	10/27/2014		J			1,049,472	(2)	(2)	Common Stock	66,129(2)	(2)	0	I(3)	Through Deerfield Special Situations Fund, L.P.(4)(5)
Series D Purchase Right	(2)	10/27/2014		J			838,067	(2)	(2)	Common Stock	52,808(2)	(2)	0	I(3)	Through Deerfield Special Situations International Master Fund, L.P.(4)(5)

1. Name and Address of Reporting Person* Flynn James E (Last) (First) (Middle) 780 THIRD AVENUE, 37TH FLOOR (Street) NEW YORK NY 10017 (City) (State) (Zip)

1. Name and Address of Reporting Person* Deerfield Mgmt L.P. (Last) (First) (Middle) 780 THIRD AVENUE, 37TH FLOOR (Street) NEW YORK NY 10017 (City) (State) (Zip)

1. Name and Address of Reporting Person* DEERFIELD MANAGEMENT CO (Last) (First) (Middle) 780 THIRD AVENUE, 37TH FLOOR (Street) NEW YORK NY 10017 (City) (State) (Zip)

1. Name and Address of Reporting Person* Deerfield Special Situations Fund, L.P. (Last) (First) (Middle) 780 3RD AVENUE 37TH FLOOR (Street) NEW YORK NY 10017 (City) (State) (Zip)

1. Name and Address of Reporting Person* Deerfield Special Situations International Master Fund, L.P. (Last) (First) (Middle) 780 THIRD AVENUE, 37TH FLOOR (Street) NEW YORK NY 10017 (City) (State) (Zip)

1. Name and Address of Reporting Person* Deerfield Mgmt III, L.P. (Last) (First) (Middle) 780 THIRD AVENUE, 37TH FLOOR (Street) NEW YORK NY 10017 (City) (State) (Zip)

1. Name and Address of Reporting Person* Deerfield Private Design Fund III, L.P. (Last) (First) (Middle) 780 THIRD AVENUE, 37TH FLOOR (Street) NEW YORK NY 10017 (City) (State) (Zip)

Explanation of Responses:

1. Each share of Series D Preferred Stock was convertible into 0.063 shares of the Issuer's common stock (on an adjusted basis, after giving effect to the 1-for-15.87 reverse stock split effected by the Issuer on October 6, 2014), plus an additional number of shares in respect of an anti-dilution adjustment based upon the offering price and participation in the initial public offering. Shares of Series D Preferred Stock had no expiration date and automatically converted into shares of the Issuer's common stock upon the closing of the Issuer's initial public offering of common stock.

2. The Series D Purchase Right entitled the holder to purchase shares of Series D Convertible Preferred Stock under the Series D Preferred Stock purchase agreement at a price of $0.588656 per share of Series D Preferred Stock, which right to purchase ceased to be exercisable upon the initial filing of the Issuer's registration statement for its initial public offering, and terminated upon the completion of the Issuer's initial public offering of common stock. Each share of Series D Preferred Stock issuable upon exercise of the Series D Purchase Right would have been convertible into shares of the Issuer's common stock as described in footnote (1) above.

3. This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the "Reporting Persons").

4. Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. ("Fund III"). Deerfield Mgmt, L.P. is the general partner of Deerfield Special Situations Fund, L.P. and Deerfield Special Situations International Master Fund, L.P. (collectively with Fund III, the "Funds"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P. and Deerfield Management Company, L.P.

5. In accordance with Instruction 5 (b)(iv) to Form 3, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise.

Remarks:

Jonathan Isler, Attorney-in-Fact: Power of Attorney, which is hereby incorporated by reference to Exhibit 24 to a Form 3 with regard to Avalanche Biotechnologies, Inc. filed with the Securities and Exchange Commission on July 30, 2014 by Deerfield Mgmt III, L.P., Deerfield Mgmt, L.P., Deerfield Management Company, L.P., Deerfield Special Situations Fund, L.P., Deerfield Special Situations International Master Fund, L.P., Deerfield Private Design Fund III, L.P. and James E. Flynn

	/s/ Jonathan Isler	10/27/2014
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
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